Didox is a simple, synthetic antioxidant that has been found to reduce the levels of oxidative injury markers. Studies have also shown that didox increases the radiosensitivity of cancer cells by inhibition of ribonucleotide reductase, resulting in a reduction of bcl-2 mediated apoptosis resistance.
1. Inayat, Mohammed S., et al., . Didox (a novel ribonucleotide reductase inhibitor) overcomes Bcl-2 mediated radiation resistance in prostate cancer cell line PC-3. Cancer biology & therapy. 1(5): 539-45. PMID: 12496485
2. Turchan, J., et al., 2003. Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants. Neurology. 60(2): 307-14. PMID: 12552050
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