Didox A synthetic antioxidant that reduces oxidative injury levels

Didox (CAS 69839-83-4)

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Synonym: N-3,4-tridhydroxy-benzamide
Application: A synthetic antioxidant that reduces oxidative injury levels
CAS Number: 69839-83-4
Purity: ≥98%
Molecular Weight: 169.13
Molecular Formula: C7H7NO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Didox is a simple, synthetic antioxidant that has been found to reduce the levels of oxidative injury markers. Studies have also shown that didox increases the radiosensitivity of cancer cells by inhibition of ribonucleotide reductase, resulting in a reduction of bcl-2 mediated apoptosis resistance.


References

1. Inayat, Mohammed S., et al., . Didox (a novel ribonucleotide reductase inhibitor) overcomes Bcl-2 mediated radiation resistance in prostate cancer cell line PC-3. Cancer biology & therapy. 1(5): 539-45. PMID: 12496485
2. Turchan, J., et al., 2003. Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants. Neurology. 60(2): 307-14. PMID: 12552050

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3045
SMILES :
C1=CC(=C(C=C1C(=O)NO)O)O

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Certificate of Analysis

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