DFB An allosteric potentiator of mGluR-5

DFB  (CAS 15332-10-2)

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Application: An allosteric potentiator of mGluR-5
CAS Number: 15332-10-2
Purity: ≥99%
Molecular Weight: 244.24
Molecular Formula: C14H10F2N2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
DFB sc-203918 10 mg $95.00
DFB sc-203918A 50 mg $379.00

DFB is a selective allosteric potentiator of metabotropic glutamate receptor type 5 (mGluR-5). DFB shows no agonist activity itself, but potentiates the action of other agonists at the mGluR-5 receptor site (3-6-fold), without any effect at other mGluR types.


References

1. O'Brien, J.A., et al. 2003. Mol. Pharmacol. 64: 731-740. PMID: 12920211
2. Zhang, Y., et al. 2005. J. Pharmacol. Exp. Ther. 315: 1212-1219. PMID: 16135701

Physical State :
Solid
Solubility :
Soluble in ethanol (10 mM), and DMSO (50 mM). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
139-141° C
Boiling Point :
326.62° C at 760 mmHg (Predicted)
Density :
1.13 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
IC50 :
mGluR-5: EC5050 = 2.36 nM (human)
pK Values :
pKb: 5.78 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6604893
MDL Number :
MFCD03653615
SMILES :
C1=CC(=CC(=C1)F)C=NN=CC2=CC(=CC=C2)F

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Certificate of Analysis

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