DFB is a selective allosteric potentiator of metabotropic glutamate receptor type 5 (mGluR-5). DFB shows no agonist activity itself, but potentiates the action of other agonists at the mGluR-5 receptor site (3-6-fold), without any effect at other mGluR types.
1. O'Brien, J.A., et al. 2003. Mol. Pharmacol. 64: 731-740. PMID: 12920211 2. Zhang, Y., et al. 2005. J. Pharmacol. Exp. Ther. 315: 1212-1219. PMID: 16135701
Soluble in ethanol (10 mM), and DMSO (50 mM). Insoluble in water.
Store at 4° C
326.62° C at 760 mmHg (Predicted)
1.13 g/cm3 (Predicted)
n20D 1.54 (Predicted)
mGluR-5: EC5050 = 2.36 nM (human)
pKb: 5.78 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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