Dextran Sulfate, Sodium Salt MW ~500,000 A nucleic acid hybridization accelerant

Dextran Sulfate, Sodium Salt MW ~500,000 (CAS 9011-18-1)

Dextran Sulfate, Sodium Salt MW ~500,000 | CAS 9011-18-1 is rated 5.0 out of 5 by 1.
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Synonym: Sodium dextran sulfate
Application: A nucleic acid hybridization accelerant
CAS Number: 9011-18-1
Molecular Weight: ~500,000
* Refer to Certificate of Analysis for lot specific data (including water content).
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Dextran sulfate is an anionic polymer of sulfated glucose, capable of accelerating hybridization rates of nucleic acids. The polyanionic character of Dextran sulfate helps to approximate nucleic acid strands, increasing their effective concentration to each other and promoting hybridization. Dextran sulfate also demonstrates a sequestering interaction with proteins, presumably through hydrogen-bonding between the sulfate groups and amine groups of the protein that generates an insoluble complex. The ability of the polymer to precipitate fibrinogen and low-density lipoproteins from plasma solutions has been used for analysis and for anticoagulant applications.


References

1. Sasaki, S. and Noguchi, H. 1959. J. Gen. Physiol. 43: 1-12. PMID: 14441863
2. Kritchevsky, D., et al. 1963. Proc. Soc. Exp. Biol. Med. 112: 259-262. PMID: 14035854
3. Nishida, T. and Cogan, U. 1970. J. Biol. Chem. 245: 4689-4697. PMID: 5456144
4. Wahl, G.M., et al. 1979. Proc. Natl. Acad. Sci. U.S.A. 76: 3683-3687. PMID: 291033
5. Lederman, L.L., et al. 1981. Anal. Biochem. 117: 158-163. PMID: 6172056
6. Warnick, G.R., et al. 1982. Clin. Chem. 28: 1379-1388. PMID: 7074948

Physical State :
Solid
Solubility :
Soluble in water (100 mg/ml).
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
HH9290000
Merck Index :
14: 2951
MDL Number :
MFCD00081551

Download SDS (MSDS)

Certificate of Analysis

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Dextran Sulfate, Sodium Salt MW ~500,000  Product Citations

See how others have used Dextran Sulfate, Sodium Salt MW ~500,000. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 18809489  Koyama, Y. et al. 2008. J. Chem. Neuroanat. 36: 209-215.

PMID: # 8359087  Murthy, SN. et al. 1993. Dig. Dis. Sci. 38: 1722-1734.

Citations 1 to 2 of 2 total

Question regarding Dextran Sulfate, Sodium Salt (CAS 9011-18-1). Can this product be stored in the refrigerator/ freezer after being dissolved in an aqueous solution and retain it's stability? Or is it only stable long-term as a powder?

Asked by: cak445564
Thank you for your question. This can be stored for at least a year at room temperature when made at a 50% solution in water.
Answered by: Technical Support
Date published: 2018-11-22

Question is regarding dextran sodium sulfate salt (DSS), Cas number 9011-18-1. Could you please tell me the MW range? Also, do you have pricing for e.g. 100 g? Thanks.

Asked by: A Kasirer
Thank you for your question. The molecular weight for Dextran Sulfate, Sodium Salt is ~500,000. Please contact our Special Orders Department to inquire about availability and pricing for a bulk quantity such as 100 g. Please call us toll-free at (800) 457-3801 option 2, or e-mail <specialorders@scbt.com>.
Answered by: Technical Support
Date published: 2017-11-17

Goog afternon, what is the purity of the product?

Asked by: Peterove
Dear Peterove, thank you very much for your interest in our product. The purity is ≥ 98%. If you have any further question, please contact our European Support office by phone: toll-free 00800 4573 8000, email europe@scbt.com or live chat.
Answered by: Technical Support Europe
Date published: 2017-09-26

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Dextran Sulfate, Sodium Salt, sc-203917, is in white to off-white crystalline powder form.
Answered by: Chemical Support 4
Date published: 2017-11-16
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Rated 5 out of 5 by from Various publications cite the use of Sodium Various publications cite the use of Sodium Dextran Sulfate (Dextran Sulfate, Sodium Salt) for its capability of accelerating hybridization rates of nucleic acids. It has also been used for anticoagulant applications due to its ability to precipitate fibrinogen and low-density lipoproteins from plasma solutions. -SCBT Publication Review
Date published: 2015-05-07
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