Dexamethasone is an antiinflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein in vitro. Dexamethasone has been observed to induce apoptosis in human thymocytes and eosinophils, but inhibits apoptosis in neutrophils in vitro. Dexamethasone is an activator of IDO.
1. Moncada, S., et al., 1991. Inhibition of the induction of nitric oxide synthase by glucocorticoids: yet another explanation for their anti-inflammatory effects? Trends in pharmacological sciences. 12(4): 130-1. PMID: 1712139 2. Clark, M A., et al., 1986. Differential effects of aspirin and dexamethasone on phospholipase A2 and C activities and arachidonic acid release from endothelial cells in response to bradykinin and leukotriene D4. Prostaglandins. 32(5): 703-8. PMID: 3103170 3. Fearnhead, H O., et al., 1994. Dexamethasone and etoposide induce apoptosis in rat thymocytes from different phases of the cell cycle. Biochemical pharmacology. 48(6): 1073-9. PMID: 7945400 4. Jaiswal, N., et al., 1997. Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. Journal of cellular biochemistry. 64(2): 295-312. PMID: 9027589 5. Chauhan, D., et al., 2000. SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells. The Journal of biological chemistry. 275(36): 27845-50. PMID: 10880513
Recommended working concentration: 500-1000 nM
Soluble in ethanol (25 mg/ml), and DMSO (25 mg/ml). Insoluble in water.
Store at room temperature
262-264° C (lit.)
~568.2° C at 760 mmHg (Predicted)
~1.3 g/cm3 (Predicted)
n20D 1.59 (Predicted)
α20/D 75°, c = 1 in doxane
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
My horse has recurrent airway obstruction and I am looking for a corticosteroid to nebulize him with along with albuterol. Is there anything other than Dex as my vet worries about him getting founder even though he is on a constant diet. Thank you
Rated 5 out of
Dexamethasone (CAS 50Dexamethasone (CAS 50-02-2) was used to determine glucocorticoid receptor binding within the human genome by measuring the change in mRNA expression after treatment (PubMed ID 19801529). -SCBT Publication Review
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