Deoxymannojirimycin hydrochloride A mannose analog that inhibits mammalian Golgi-α-mannosidase I

Deoxymannojirimycin hydrochloride (CAS 84444-90-6)

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Synonym: DMJ
Application: A mannose analog that inhibits mammalian Golgi-α-mannosidase I
CAS Number: 84444-90-6
Purity: ≥98%
Molecular Weight: 199.6
Molecular Formula: C6H13NO4•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Deoxymannojirimycin HCl is a mannose analog that inhibits mammalian MAN1A2 (Golgi-alpha-mannosidase I) at the active site. Known to block the biosynthesis of complex oligosaccharides. However, it does not block endoplasmic reticulum alpha-mannosidase. Observed to induce disorganization of the extracellular matrix fibronectin assembly. Also, deoxymannojirimycin treated in hepatocarcinoma H7721 cells resulted in ER stress and apoptosis.


References

1. Gross, V., et al. 1985. Eur. J. Biochem. 150: 41-46. PMID: 3160588
2. Bischoff, J., et al. 1986. J. Biol. Chem. 261: 4766-4774. PMID: 2937779
3. Suzuki, S.S., et al. 1993. J. Cell. Biochem. 51: 181-189. PMID: 8440752
4. Lu, Y., et al. 2006. Biochem. Biophys. Res. Commun. 344: 221-225. PMID: 16615997

Physical State :
Solid
Solubility :
Soluble in water (50 mM), methanol (warm), and DMSO.
Storage :
Store at -20° C
Melting Point :
197.5-198.7° C
Boiling Point :
361.1° C at 760 mmHg
Refractive Index :
n20D 1.58
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11390018
MDL Number :
MFCD00083611
SMILES :
C1C(C(C(C(N1)CO)O)O)O.Cl

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Deoxymannojirimycin hydrochloride  Product Citations

See how others have used Deoxymannojirimycin hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 20209334  Mora-Montes, HM. et al. 2010. Mem. Inst. Oswaldo Cruz. 105: 79-85.

PMID: # 3159432  Fuhrmann, U. et al. 1985. Biochim. Biophys. Acta. 825: 95-110.

Citations 1 to 2 of 2 total
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