Deferoxamine Mesylate, an iron chelator, has been found to inhibit thymidine incorporation in cell cultures which is antagonized by iron supplementation. Iron has been reported to be involved in the control of enzymatic activities that regulate DNA synthesis in cells. This compound has also been reported to induce apoptosis by causing chromatin condensation. Additionally, Deferoxamine Mesylate demonstrates the ability to induce p53 and cell accumulation in the G1 phase of cell growth and increase p21 mRNA levels without any detectable protein products. Furthermore, studies suggest that this agent is capable of activating HIF-1α (hypoxia-inducible factor 1α), consequently causing transcription of numerous genes that are associated with hypoxia. Deferoxamine Mesylate is an inhibitor of Prolyl Hydroxylase.
1. Porreca, E., et al. 1994. Arterioscler. Thromb. 14: 299-304. PMID: 8305423 2. Fukuchi, K., et al. 1994. FEBS Lett. 350: 139-142. PMID: 8062913 3. Fukuchi, K., et al. 1998. Biochim. Biophys. Acta. 1404: 405-411. PMID: 9739169 4. An, W.G., et al. 1998. Nature. 392: 405-408. PMID: 9537326
Soluble in water (50 mg/ml), and ethanol (1:20). Insoluble in dehydrated alcohol, chloroform, and ether.
Thank you for your question. Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 12 months.
Wherever possible, we recommend to prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Answered by: Technical Support
Date published: 2018-05-31
Is the desired solvent for this product water?
Asked by: 13punMA
Thank you for asking about our product Deferoxamine mesylate (CAS# 138-14-7). The desired solvent is indeed water.
Rated 5 out of
ChoiChoi, et al. (PubMed ID 26339170) found that Deferoxamine induced HIF-1 in a dose-dependent manner in human small airway epithelial cells (HSAEpCs). -SCBT Publication Review
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