Deferasirox A tridentate chelator that binds iron with high affinity

Deferasirox (CAS 201530-41-8)

Deferasirox | CAS 201530-41-8 is rated 5.0 out of 5 by 1.
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Synonym: 4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic Acid; Exjade; ICL-670; ICL-670A; CGP-72670
Application: A tridentate chelator that binds iron with high affinity
CAS Number: 201530-41-8
Purity: ≥99%
Molecular Weight: 373.36
Molecular Formula: C21H15N3O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Deferasirox is a tridentate iron chelator that binds iron with high affinity in a 2:1 ratio. Although deferasirox has very low affinity for zinc and copper, there are variable decreases in the serum concentration of these trace metals after the administration of deferas.


References

Hershko, C., et al.: Blood, 97, 1115 (2001), Galanello, R., et al.: J. Clin. Pharmacol., 43, 565 (2003), Nick, H., et al.: Curr. Med. Chem., 10, 1065 (2003),

Physical State :
Solid
Solubility :
Soluble in water (<1 mg/ml at 25° C), DMSO (75 mg/ml at 25° C), ethanol (2 mg/ml at 25° C), methanol, and ethyl acetate.
Storage :
Store at -20° C
Melting Point :
258-263° C
Boiling Point :
~672.1° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.70 (Predicted)
IC50 :
MDA-MB-231: IC50 = 4 µM (human); MIA PaCa-2 : IC50 = 10 µM (human); SK-N-MC: IC50 = 20.54 µM (human); ADMET: IC50 = 0.1 mM (human)
pK Values :
pKa: 3.54 (Predicted), pKb: 0.35 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
DG4438400
PubChem CID :
5493381
MDL Number :
MFCD09951804
Beilstein Registry :
8442898
SMILES :
C1=C/C(=C/2\N/C(=C\3/C=CC=CC3=O)/N(N2)C4=CC=C(C=C4)C(=O)O)/C(=O)C=C1

Download SDS (MSDS)

Certificate of Analysis

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Deferasirox  Product Citations

See how others have used Deferasirox. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25779532  Jung, IR. et al. 2015. Molecular and cellular endocrinology. 407: 74-84.

PMID: # 26006106  Dev, S. et al. 2015. Free Radic. Biol. Med. 86: 78-89.

Citations 1 to 2 of 2 total

Is the deferasirox in your website a primary standard that can be used in analysis

Asked by: Iman
Thank you for your question. Please contact our technical service so we can send you a lot-specific certificate of analysis for the lot of Deferasirox (CAS 201530-41-8) that would be currently available.
Answered by: SCBT Heidelberg Support
Date published: 2019-01-06

I've dissolved it in DMSO and aliqouted it. But if I am adding it into my stock staining solution pipette tip is getting frozen due to the DMSO I assume. So how can I prevent it?

Asked by: Liss
We recommend to store the aliquoted solution in the freezer, then completely thaw it before use. Once completely thawed, the solution will be not cause the pipette tip to freeze.
Answered by: Technical Support
Date published: 2018-12-12

Any suggestions on how to dissolve in water?

Asked by: SCchem16
Thank you for your question. This chemical, Deferasirox (CAS 201530-41-8), is not very soluble in water and it is suggested to use DMSO which is soluble at 75mg/ml.
Answered by: Chemical Support 2
Date published: 2018-12-11
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Rated 5 out of 5 by from Morita Morita, T. et al. (PubMed 25820160) investigated the effect of iron chelation on renal cell senescence and inflammation in type I diabetic mouse kidney. Administration of Deferasirox (Exjade; ICL-670; ICL-670A; CGP-72670), a high affinity iron chelator, significantly attenuated iron accumulation in proximal tubules and the number of infiltrating F4/80-positive cells without effecting blood glucose, hematocrit or hemoglobin levels. In contrast however, Deferasirox did not influence renal cell senescence. -SCBT Publication Review
Date published: 2015-07-04
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