DAPT is a potent and specific inhibitor of γ-secretase. It has been shown to cause a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ40 and Aβ42 respectively). There is evidence that DAPT does not effect APPα and APPβ levels. It mimics notch signaling deficiencies at morphological, molecular and biochemical levels and has been shown to block notch signaling in hybrid human-mouse foetal thymus organ culture (FTOC).
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See how others have used DAPT. Click on the entry to view the PubMed entry .
PMID: # 28771710 Lee, ML. et al. 2017. J. Neurochem.
PMID: # 26746659 Dinicola, S. et al. 2016. Life Sci. 145: 174-83.
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PMID: # 26355082 Kwon, YC. et al. 2015. J. Virol. 89: 11549-56.
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PMID: # 24881778 Richardson, T. et al. 2014. Tissue Eng Part A. 20: 3198-211.
PMID: # 23188126 You, J. et al. 2013. Journal of cardiovascular pharmacology. 61: 142-51.
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