Dapsone A leukotriene B4 antagonist that inhibits LTB4 induced lysozyme release

Dapsone (CAS 80-08-0)

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Application: A leukotriene B4 antagonist that inhibits LTB4 induced lysozyme release
CAS Number: 80-08-0
Purity: ≥97%
Molecular Weight: 248.30
Molecular Formula: C12H12N2O2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Dapsone is a leukotriene B4 (LTB4) antagonist. Inhibits LTB4 induced lysozyme release.


References

Dapsone inhibits LTB4 binding and bioresponse at the cellular and physiologic levels: B.L. Maloff, et al.; Eur. J. Pharmacol. 158, 85 (1988)

Physical State :
Solid
Solubility :
Soluble in water, DMSO, ethanol, methanol, and acetone.
Storage :
Store at room temperature
Melting Point :
175-177° C (lit.)
Boiling Point :
476.7-546.7° C at 760 mmHg (Predicted)
Density :
1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 11.7 nM; Dihydropteroic acid synthase (SYN): IC50 = 1.18 µM; Dihydrofolate reductase: IC50 = 1.5 µM (Pneumocystis carinii); Dihydropteroate synthetase, putative: IC50 = 12.41 µM (Plasmodium berghei str. ANKA)
Ki Data :
AZT glucuronidation : Ki= 1700 µM (human)
pK Values :
pKa: 2.41, pKb: 1.24 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
BY8925000
PubChem CID :
2955
Merck Index :
14: 2822
MDL Number :
MFCD00007887
EC Number :
201-248-4
Beilstein Registry :
788055
SMILES :
C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N

Download SDS (MSDS)

Certificate of Analysis

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