Damnacanthal An immunomodulator and potent inhibitor of p56lck tyrosine kinase

Damnacanthal (CAS 477-84-9)

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Application: An immunomodulator and potent inhibitor of p56lck tyrosine kinase
CAS Number: 477-84-9
Purity: 95%
Molecular Weight: 282.25
Molecular Formula: C16H10O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Damnacanthal, an anthraquinone isolated from roots of Morinda elliptica, has been reported as a selective and potent inhibitor of Lck (p56lck tyrosine kinase) activity. Mechanistic studies have shown Damnacanthal to be mixed noncompetitive with the ATP site, competitive with the peptide binding site, and bind nonspecifically to membrane lipids. Other studies have shown Damnacanthal to have immunomodulatory effects by activating mouse thymocytes and peripheral blood mononuclear cells (PBMC). In addition, Viral Protein R, a protein that contributes to apoptosis, multiple cytopathic effects, and G2 cell cycle arrest has been proven to be inhibited by Damnacanthal.


References

1. Faltynek, C.R., et al. 1995. Biochemistry. 34: 12404-12410. PMID: 7547985
2. Kamata, M., et al. 2006. Biochem. Biophys. Res. Commun. 348: 1101-1106. PMID: 16904642
3. Alitheen, N.B., et al. 2010. Pharm Biol. 48: 446-452. PMID: 20645725

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml).
Storage :
Store at -20° C
Melting Point :
195.36° C
Boiling Point :
~531.9° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.69
IC50 :
p56lck autophosphorylation: IC50 = 17 nM; phosphorylation of an exogenous peptide by p56lck: IC50 = 620 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
2948
SMILES :
COC1=C2C(=CC(=C1C=O)O)C(=O)C3=CC=CC=C3C2=O

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Certificate of Analysis

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Damnacanthal  Product Citations

See how others have used Damnacanthal. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 7547985  Faltynek, CR. et al. 1995. Biochemistry. 34: 12404-12410.

Citations 1 to 1 of 1 total
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