Damnacanthal, an anthraquinone isolated from roots of Morinda elliptica, has been reported as a selective and potent inhibitor of Lck (p56lck tyrosine kinase) activity. Mechanistic studies have shown Damnacanthal to be mixed noncompetitive with the ATP site, competitive with the peptide binding site, and bind nonspecifically to membrane lipids. Other studies have shown Damnacanthal to have immunomodulatory effects by activating mouse thymocytes and peripheral blood mononuclear cells (PBMC). In addition, Viral Protein R, a protein that contributes to apoptosis, multiple cytopathic effects, and G2 cell cycle arrest has been proven to be inhibited by Damnacanthal.
1. Faltynek, C.R., et al. 1995. Biochemistry. 34: 12404-12410. PMID: 7547985 2. Kamata, M., et al. 2006. Biochem. Biophys. Res. Commun. 348: 1101-1106. PMID: 16904642 3. Alitheen, N.B., et al. 2010. Pharm Biol. 48: 446-452. PMID: 20645725
Soluble in DMSO (25 mg/ml).
Store at -20° C
~531.9° C at 760 mmHg (Predicted)
~1.5 g/cm3 (Predicted)
p56lck autophosphorylation: IC50 = 17 nM; phosphorylation of an exogenous peptide by p56lck: IC50 = 620 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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See how others have used Damnacanthal. Click on the entry to view the PubMed entry
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