DAMGO A highly selective peptide agonist for the mu-opioid receptor

DAMGO (CAS 78123-71-4)

DAMGO | CAS 78123-71-4 is rated 5.0 out of 5 by 1.
  • y_2019, m_4, d_21, h_11
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_391800, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 89ms
  • REVIEWS, PRODUCT
Synonym: [D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin; DAGO
Application: A highly selective peptide agonist for the mu-opioid receptor
CAS Number: 78123-71-4
Molecular Weight: 513.59
Molecular Formula: C26H35N5O6
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

DAMGO is a highly selective peptide agonist for the μ opioid receptor.
Sequence: YAGFG (Modifications: Ala-2 = D-Ala, Phe-4 = N-methyl-Phe, Gly-5 = Gly-ol)

Physical State :
Solid
Sequence :
Tyr-D-Ala-Gly-NMe-Phe-Gly-ol
Solubility :
Soluble in water (2 mg/ml).
Storage :
Desiccate at -20° C
Boiling Point :
~922.7° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
IC50 :
MOR-1: IC50 = 0.68 nM (human); Mu opioid receptor: IC50 = 1.01 nM (rat); DOR-1: IC50 = 1.45 nM (human); Cavia porcellus: IC50 = 8.25 nM; Mu opioid receptor: IC50 = 11.5 nM (Cavia porcellus)
Ki Data :
MOR-1: Ki= 0.28 nM (human); Mu opioid receptor: Ki= 0.53 nM (rat); DOR-1: Ki= 0.66 nM (human); Mu opioid receptor: Ki= 0.99 nM (Cavia porcellus); CCK-BR: Ki= 11 nM (human)
pK Values :
pKa: 9.97 (Predicted), pKb: 7.24 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5462471
SMILES :
C[C@H](C(=O)NCC(=O)N(C)[C@@H](CC1=CC=CC=C1)C(=O)NCCO)NC(=O)[C@H](CC2=CC=C(C=C2)O)N

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 52ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Posa et al Posa et al. (PubMed ID 26390873) found that the selective peptide agonist for the mu-opioid receptor, DAMGO, reduced tolerance to morphine. -SCBT Publication Review
Date published: 2015-02-17
  • y_2019, m_4, d_21, h_11
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_391800, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 228ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.