Dalfopristin is a semi-synthetic analogue of ostreogyrcin A (virginiamycin M, pristinamycin IIA, streptogramin A) formed by addition of diethylaminoethylthiol to the 2-pyrroline group of ostreogyrcin, followed by oxidation to the sulphone. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Dalfopristin is used commercially in synergistic combination with quinupristin (70:30). There is little published data on the synthesis, biological or antibiotic activity of dalfopristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.
Soluble in ethanol, methanol, DMSO, DMF, and water (0.072 mg/ml).
Store at -20° C
940.5° C at 760 mmHg
pKa: 13.18 (Predicted), pKb: 8.97 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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