Dalfopristin (as mesylate) A semi-synthetic analogue of ostreogyrcin A

Dalfopristin (as mesylate) (CAS 112362-50-2)

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Application: A semi-synthetic analogue of ostreogyrcin A
CAS Number: 112362-50-2
Molecular Weight: 787.0
Molecular Formula: C35H54N4O12S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Dalfopristin is a semi-synthetic analogue of ostreogyrcin A (virginiamycin M, pristinamycin IIA, streptogramin A) formed by addition of diethylaminoethylthiol to the 2-pyrroline group of ostreogyrcin, followed by oxidation to the sulphone. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Dalfopristin is used commercially in synergistic combination with quinupristin (70:30). There is little published data on the synthesis, biological or antibiotic activity of dalfopristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.

Physical State :
Solid
Derived From :
Semi-synthetic
Solubility :
Soluble in ethanol, methanol, DMSO, DMF, and water (0.072 mg/ml).
Storage :
Store at -20° C
Boiling Point :
940.5° C at 760 mmHg
Density :
1.27 g/cm3
Refractive Index :
n20D 1.58
pK Values :
pKa: 13.18 (Predicted), pKb: 8.97 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
21943994
MDL Number :
MFCD00895414
SMILES :
CCN(CC)CCS(=O)(=O)[C@@H]1CCN2[C@H]1C(=O)O[C@@H]([C@@H](/C=C\C(=O)NC/C=C\C(=C/[C@H](CC(=O)CC3=NC(=CO3)C2=O)O)\C)C)C(C)C

Download SDS (MSDS)

Certificate of Analysis

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