D-Fructose 1,6-bisphosphate trisodium salt octahydrate A common metabolic sugar that is an allosteric activator of enzymes such as pyruvate kinase

D-Fructose 1,6-bisphosphate trisodium salt octahydrate (CAS 81028-91-3)

D-Fructose 1,6-bisphosphate trisodium salt octahydrate | CAS 81028-91-3 is rated 5.0 out of 5 by 1.
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Synonym: D-Fructose 1,6-diphosphate trisodium salt; FDP-Na3H
Application: A common metabolic sugar that is an allosteric activator of enzymes such as pyruvate kinase
CAS Number: 81028-91-3
Purity: ≥98%
Molecular Weight: 550.18
Molecular Formula: C6H11O12P23Na•8H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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D-Fructose-1,6-bisphosphate, a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. D-Fructose 1,6-bisphosphate trisodium salt octahydrate is an activator of PKLR and PKM2. D-Fructose 1,6-bisphosphate trisodium salt octahydrate is also a substrate of Aldolase, liver FBPaseand and muscle FBPase. It is an allosteric activator of enzymes such as pyruvate kinase and a substrate used to identify and characterize enzymes such as fructose-1,6-bisphosphate aldolase(s) and fructose-1, 6-bisphosphatase(s). D-Fructose-1,6-bisphosphate is studied as a neuroprotective agent in brain injury.

Physical State :
Solid
Storage :
Desiccate at 4° C
Melting Point :
100-110° C (dec.)
Density :
~1.65 g/cm3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16213208
MDL Number :
MFCD00149340
EC Number :
253-778-0
SMILES :
C([C@@H]1[C@H]([C@@H]([C@](O1)(COP(=O)(O)[O-])O)O)O)OP(=O)([O-])[O-].O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+]

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Rated 5 out of 5 by from Song Song, X. et al. (PubMed 16501318) presented evidence that suggests D-Fructose 1,6-bisphosphate (FBP) has a neuroprotective effect against -amyloid induced neurotoxicity in hippocampal slice cultures. Additionally, their research suggests that FBP plays a role not only as an alternative energy source, but also a modulator of PLC and MEK/ERK pathways to regulate the cellular response and survival. -SCBT Publication Review
Date published: 2015-03-06
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