D-Fructose-1,6-bisphosphate, a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. D-Fructose 1,6-bisphosphate trisodium salt octahydrate is an activator of PKLR and PKM2. D-Fructose 1,6-bisphosphate trisodium salt octahydrate is also a substrate of Aldolase, liver FBPaseand and muscle FBPase. It is an allosteric activator of enzymes such as pyruvate kinase and a substrate used to identify and characterize enzymes such as fructose-1,6-bisphosphate aldolase(s) and fructose-1, 6-bisphosphatase(s). D-Fructose-1,6-bisphosphate is studied as a neuroprotective agent in brain injury.
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For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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SongSong, X. et al. (PubMed 16501318) presented evidence that suggests D-Fructose 1,6-bisphosphate (FBP) has a neuroprotective effect against -amyloid induced neurotoxicity in hippocampal slice cultures. Additionally, their research suggests that FBP plays a role not only as an alternative energy source, but also a modulator of PLC and MEK/ERK pathways to regulate the cellular response and survival. -SCBT Publication Review
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