D-Cycloserine Antibiotic and a partial agonist of NMDA receptors at the glycine modulatory site

D-Cycloserine (CAS 68-41-7)

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Synonym: (R)-4-Amino-3-isoxazolidone
Application: Antibiotic and a partial agonist of NMDA receptors at the glycine modulatory site
CAS Number: 68-41-7
Purity: ≥98%
Molecular Weight: 102.1
Molecular Formula: C3H6N2O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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D-Cycloserine is a partial agonist of NMDA receptors at the glycine site. D-Cycloserine has experimentally been shown to facilitate activation of the receptor and thereby improve memory and cognition. An amino acid analog, D-Cycloserine inhibits bacterial cell wall biosynthesis.


References

1. Hood, W.F., et al. 1989. Neurosci. Lett. 98: 91-95. PMID: 2540460
2. Baran, H., et al. 1994. Brain Res. 65: 195-200. PMID: 7953730
3. Tsai, G.E., et al. 1999. Am J Psychiatry. 156: 467-469. PMID: 10080566
4. Pussinen, R. and Sirviö, J. 1999. J. Psychopharmacol. 13: 171-179. PMID: 10475724

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (100 mg/ml), methanol (Slightly soluble), propylene glycol (Slightly soluble), Alkaline Aqueous Buffer (pH 10.0), 0.1 M phosphate pH 8.0 (10 mg/ml), and 96% ethanol (1:50). Insoluble in chloroform, and ether.
Storage :
Store at 4° C
Melting Point :
147° C (lit.)(dec.)
Density :
1.28 g/cm3 (Predicted)
Refractive Index :
n20D 1.48 (Predicted)
Optical Activity :
α23/D +115°, c = 1.0 in water
IC50 :
Glutamate NMDA receptor: IC50 = 2.3 µM (Rattus norvegicus); Glutamate (NMDA) receptor subunit zeta 1: IC50 = 7.37 µM (Rattus norvegicus); UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase: IC50 = 300 µM (Staphylococcus epidermidis (strain ATCC 35984 / RP62A)); Glutamate [NMDA] receptor subunit epsilon 3: EC5050 = 18.1 µM (Rattus norvegicusHomologous )
Ki Data :
Escherichia coli DdlB: Ki= 22 µM; D-alanine-D-alanine ligase B : Ki= 27 µM (Escherichia coli)
pK Values :
pKb: 5.93
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
NY2975000
PubChem CID :
6234
Merck Index :
14: 2751
MDL Number :
MFCD00005353
EC Number :
200-688-4
Beilstein Registry :
80798
SMILES :
C1[C@H](C(=O)NO1)N

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Certificate of Analysis

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D-Cycloserine  Product Citations

See how others have used D-Cycloserine. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 10080566  Tsai, GE. et al. 1999. Am J Psychiatry. 156: 467-469.

PMID: # 10475724  Pussinen, R. et al. 1999. J. Psychopharmacol. (Oxford). 13: 171-179.

PMID: # 7953730  Baran, H. et al. 1994. Brain Res. 652: 195-200.

PMID: # 2540460  Hood, WF. et al. 1989. Neurosci. Lett. 98: 91-95.

Citations 1 to 4 of 4 total
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