Cytokeratin 17 (V-17) will be discontinued December 31, 2016; to receive a 10 µg sample of Cytokeratin 17 (E-4): sc-393002, our highly recommended and much superior monoclonal antibody alternative to this product, please contact Technical Service.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Cytokeratin 17 is a member of the Cytokeratin subfamily of intermediate filament proteins (IFPs). It is unique in that it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Cytokeratin 17 contains 432 amino acids and is expressed in the nail bed, hair follicle, sebaceous glands and other epidermal appendages. Cytokeratin 17 functions to regulate cell growth and size through its interactions with the adaptor protein 14-3-3-sigma to mediate protein synthesis. Mutations in the gene encoding for Cytokeratin 17 lead to depressed protein translation and smaller sized skin keratinocytes, corresponding to decreased Akt/mTOR signaling activity. Cytokeratin 17 may be a useful marker for cervical stem cell identification, squamous cell carcinoma of the larynx, respiratory syncytial virus and transitional cell carcinomas of the human urinary tract.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PMID: # 23049838 D'Amato, NC. et al. 2012. Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system. PloS one. 7: e45684.
Joan Attia et al. 2011. Modulation of collagen and keratin synthesis in co-cultures of fibroblasts and keratinocytes on hyaluronan-coated polysulfone membranes Journal of Bioactive and Compatible Polymers. 26: 71 - 88.
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 4 out of
Positive immunoperoxidase staining of formalinPositive immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining. -SCBT QC
Date published: 2015-01-13
Rated 4 out of
Positive western blot analysis of CytokeratinPositive western blot analysis of Cytokeratin 17 expression in T24 whole cell lysate. -SCBT QC
Date published: 2015-02-27
Rated 4 out of
IF publication using HMECIF publication using HMEC, MCF-7, and MDA-MB-231samples. -SCBT Publication Review
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Why create an account?
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.