CYM 5442 hydrochloride CYM 5442 hydrochloride behaves as an effective EDG-1 (S1P1) agonist, that has been shown to activate S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells.

CYM 5442 hydrochloride  (CAS 1094042-01-9)

CYM 5442 hydrochloride is rated 5.0 out of 5 by 1.
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Application: A potent, brain penetrant, and selective EDG-1 (S1P1) agonist
CAS Number: 1094042-01-9
Purity: ≥99%
Molecular Weight: 445.94
Molecular Formula: C23H27N3O4•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
CYM 5442 hydrochloride sc-311309 10 mg $195.00
CYM 5442 hydrochloride sc-311309A 50 mg $825.00

CYM 5442 hydrochloride is a potent and selective EDG-1 (S1P1) agonist in vitro (EC50 = 1.35 nM). Shown to activate S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1. Induces acute lymphopenia in mice. Brain penetrant.


References

1. Gonzalez-Cabrera, P.J., et al. 2008. Mol. Pharmacol. 74: 1308-1318. PMID: 18708635

Physical State :
Solid
Solubility :
Soluble in water (10 mM), and DMSO (100 mM).
Storage :
Store at -20° C
IC50 :
S1P1: EC5050 = 1.35 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
Cl.OCCNC1CCC2C(CCCC12)C1NOC(N1)C1CCC(OCC)C(OCC)C1

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Worked well in our experiments Worked well in our experiments, no complaints
Date published: 2015-05-15
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