PRODUCT NAME | CATALOG # | UNIT | PRICE | QTY | FAVORITES | |
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Cyclosporin A | sc-3503 | 100 mg | $55.00 |
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Cyclosporin A | sc-3503A | 500 mg | $217.00 |
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Cyclosporin A is a metabolite of the fungi Trichoderma polysporum, Cyclosporin A (CsA) is a cyclic polypeptide consisting of 9 amino-acids to inhibit nitric oxide synthesis induced by interleukin 1alpha, lipopolysaccharides and TNFα. CsA is an immunosuppressant. Studies in animals indicate that cyclosporin inhibits the development of cell-mediated reactions, including allograft immunity, delayed cutaneous hypersensitivity, experimental allergic encephalomyelitis, Freund's adjuvant arthritis, graft-versus-host disease and also T-cell dependent antibody production. Also inhibits lymphokine production and release and appears to block resting lymphocytes in the G0 or G1 phase of the cell cycle. CsA binds to cyclophilin and inhibits the T-cell receptor signal transduction pathway via the formation of cyclpsporin A-cyclophilin complex. The CsA-cyclophilin complex inhibits PP2 (calcineurin, a type 2B phosphatase). Calcineurin inhibition interferes with other physiological processes as well. It inhibits mitochondrial permeability transition pore opening. However, pore inhibition becomes less efficient at increasing Ca2+ loads and inhibition is transient. Inhibits staurosporin-induced apoptosis in cultured neural cells and rotenone-induced apoptosis in PC-12 cells.
1. Gonatas, J.O., et al. 1989. J. Biol. Chem. 264: 646-653. PMID: 2909545
2. Bernardi, P., et al. 1993. J. Biol. Chem. 268: 1005-1010. PMID: 8419309
3. Kunz, J. and Hall, M.N. 1993. Trends Biochem. Sci. 18: 334-338. PMID: 7694398
4. Liu, J. 1993. Trends Pharmacol. Sci. 14: 182-188. PMID: 7692652
5. Broekemeier, K.M., et al. 1995. Biochemistry. 34: 16440-16449. PMID: 8845372
6. Seaton, T.A., et al. 1998. Brain Res. 809: 12-17. PMID: 9795106
7. Kruman, I.I. and Mattson, M.P. 1999. J. Neurochem. 72: 529-540. PMID: 9930724
See how others have used Cyclosporin A. Click on the entry to view the PubMed entry .
PMID: # 27529070
Chen, D. et al. 2016. HMBA Enhances Prostratin-Induced Activation of Latent HIV-1 via Suppressing the Expression of Negative Feedback Regulator A20/TNFAIP3 in NF-κB Signaling. Biomed Res Int. 2016: 5173205.
PMID: # 27725441
Asai, M. et al. 2016. Perturbed Calcineurin-NFAT Signaling Is Associated with the Development of Alzheimer's Disease. Biol. Pharm. Bull.. 39: 1646-1652.
PMID: # 27552406
Kam, WR. et al. 2016. Do Cyclosporine A, an IL-1 Receptor Antagonist, Uridine Triphosphate, Rebamipide, and/or Bimatoprost Regulate Human Meibomian Gland Epithelial Cells? Invest. Ophthalmol. Vis. Sci.. 57: 4287-94.
PMID: # 25444914
Li, X. et al. 2015. Synergistic antitumor activity of withaferin A combined with oxaliplatin triggers reactive oxygen species-mediated inactivation of the PI3K/AKT pathway in human pancreatic cancer cells. Cancer letters. 357: 219-30.
PMID: # 26173181
Li, X. et al. 2015. Nur77 prevents excessive osteoclastogenesis by inducing ubiquitin ligase Cbl-b to mediate NFATc1 self-limitation. eLife. 4: e07217.
PMID: # 22767227
Cai, Q. et al. 2012. Elevated and secreted phospholipase A₂ activities as new potential therapeutic targets in human epithelial ovarian cancer. FASEB J.. 26: 3306-20.
PMID: # 21078663
Farrow, MA. et al. 2011. NFAT and IRF proteins regulate transcription of the anti-HIV gene, APOBEC3G. J. Biol. Chem.. 286: 2567-2577.
PMID: # 19555495
Krücken, J. et al. 2009. In silico analysis of the cyclophilin repertoire of apicomplexan parasites. Parasit Vectors. 2: -.
PMID: # 19680534
Kaul, A. et al. 2009. Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. PLoS Pathog.. 5: -.
PMID: # 18216318
Edemir, B. et al. 2008. Acute rejection modulates gene expression in the collecting duct. J. Am. Soc. Nephrol.. 19: 538-546.
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