Cycloheximide is a highly effective antibiotic with activity against mold, yeast, and phytopathogenic fungi, with lower activity against bacteria. It has been reported to inhibit the synthesis of both proteins and macromolecules, as well as affect apoptosis in eukaryotes. Inhibition of protein synthesis is believed to be mediated through DNA translation arrest, as demonstrated in rat thymocytes. Although cycloheximide has been reported to induce apoptosis in various cells, it has also been shown to inhibit or delay induced apoptosis. These observations suggest that cycloheximide's effect on apoptosis may not be solely through protein translation arrest and that other mechanisms may be involved. Cycloheximide has also been reported to inhibit FKBP12 (peptidylprolylisomerase hFKBP12, PPIase hFKBP12) via competitive inhibition.
1. Lotem, J. and Sachs, L. 1995. Cell Growth Differ. 6: 647-653. PMID: 7669718 2. Chow, S.C., et al. 1995. Exp. Cell Res. 216: 149-159. PMID: 7813615 3. Grand, R.J., et al. 1995. Exp. Cell Res. 218: 439-451. PMID: 7796880
Recommended working concentration in literature is 1μg/mL
Soluble in water (20 mg/ml at 2° C), ethanol (50 mM), chloroform, and ether. Insoluble in saturated hydrocarbons. (Do not store aqueous solutions for more than one day)
Thank you for your question. sc-3508 (Cycloheximide, CAS 66-81-9) is not 100% synthetic. It's semi-fermented and semi-synthetic.
Answered by: Chemical Support 10
Date published: 2017-03-09
What is the appearance of the compound?
Asked by: two2igm05
Thank you for your question. The compound, sc-3508, is provided as a white to off-white crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing firstname.lastname@example.org, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-17
What is the solubility of this product in DMSO?
Asked by: hawkeye11
Thank you for you question. Cycloheximide, sc-3508, is soluble in DMSO at 32mg/mL.
Answered by: TechService7
Date published: 2019-03-06
What is the country of origin of this compound?
Asked by: two2igm05
Thank you for your question.
This particular chemical is from China.
Please contact Technical Service if you have further questions concerning this product.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
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