Cyclic Pifithrin-alpha hydrobromide A cyclic analog of pifithrin-α

Cyclic Pifithrin-α hydrobromide (CAS 511296-88-1)

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Synonym: 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole, HBr
Application: A cyclic analog of pifithrin-α
CAS Number: 511296-88-1
Purity: ≥95%
Molecular Weight: 349.29
Molecular Formula: C16H16N2S.HBr
* Refer to Certificate of Analysis for lot specific data (including water content).

Cyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α a small molecule inhibitor of p53. It reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis, with less cytotoxicity than the parent compound. Potent STAT6 transcriptional inhibitor. This compound has been shown to prevent dexamethasone-induced cell death in murine thymocytes with an EC50value of 2.01 µM. Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents.

Physical State :
Solubility :
Soluble in DMSO (20 mg/ml), and ethanol (10 mM).
Storage :
Store at -20° C
Melting Point :
266.4-267.3° C (lit.)
IC50 :
dexamethasone-induced cell death: EC5050 = 2.01 µM (murine thymocytes); Mus musculus: EC5050 = 2.5 µM
pK Values :
pKb: 6.75 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 7421
MDL Number :

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Certificate of Analysis

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Cyclic Pifithrin-alpha hydrobromide  Product Citations

See how others have used Cyclic Pifithrin-alpha hydrobromide. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25746954  Lima, CF. et al. 2015. Eur J Pharm Sci. 72: 34-45.

Citations 1 to 1 of 1 total
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