Cyclic Pifithrin-alpha hydrobromide A cyclic analog of pifithrin-α

Cyclic Pifithrin-α hydrobromide (CAS 511296-88-1)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 317ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole, HBr
Application: A cyclic analog of pifithrin-α
CAS Number: 511296-88-1
Purity: ≥95%
Molecular Weight: 349.29
Molecular Formula: C16H16N2S.HBr
* Refer to Certificate of Analysis for lot specific data (including water content).

Cyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α a small molecule inhibitor of p53. It reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis, with less cytotoxicity than the parent compound. Potent STAT6 transcriptional inhibitor. This compound has been shown to prevent dexamethasone-induced cell death in murine thymocytes with an EC50value of 2.01 µM. Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents.

Physical State :
Solid
Solubility :
Soluble in DMSO (20 mg/ml), and ethanol (10 mM).
Storage :
Store at -20° C
Melting Point :
266.4-267.3° C (lit.)
IC50 :
dexamethasone-induced cell death: EC5050 = 2.01 µM (murine thymocytes); Mus musculus: EC5050 = 2.5 µM
pK Values :
pKb: 6.75 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11515812
Merck Index :
14: 7421
MDL Number :
MFCD02683960
SMILES :
CC1=CC=C(C=C1)C2=CN3C4=C(CCCC4)SC3=N2.Br

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Cyclic Pifithrin-alpha hydrobromide  Product Citations

See how others have used Cyclic Pifithrin-alpha hydrobromide. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25746954  Lima, CF. et al. 2015. Eur J Pharm Sci. 72: 34-45.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 78ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 9ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.