Curvularin A potent antifungal and mycotoxin that also inhibits NO production

Curvularin (CAS 10140-70-2)

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Synonym: 4,5,6,7,8,9-Hexahydro-11,13-dihydroxy-4-methyl-2H-3-benzoxacyclododecin-2,10(1H)-dione
Application: A potent antifungal and mycotoxin that also inhibits NO production
CAS Number: 10140-70-2
Purity: ≥95%
Molecular Weight: 292.30
Molecular Formula: C16H20O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Curvularin, a compound originally derived from Curvularia lunata, has been reported to be a fungal metabolite and a potent mycotoxin. Mechanistic studies suggest that spore suspension caused by this compound can produce localized lesion and hepatic necrosis. Other studies suggest that Curvularin inhibits cytokine-induced, γ activated site-dependent reporter gene expression in vitro. Additionally, this agent was shown to inhibit inducible nitric-oxide synthase-dependent NO production via modulatory action on the Janus tyrosine kinase-signal transducer and activator of transcription pathway.


References

1. Vesonder, R.F., et al. 1976. J Environ Sci Health B. 11: 289-271. PMID: 1002951
2. Rout, N., et al. 1989. Indian J Pathol Microbiol. 32: 1-6. PMID: 2592030
3. Schmidt, K. 1991. Am. J. Clin. Nutr. 53: 383S-385S. PMID: 1985416
4. Yao, Y., et al. 2003. Mol. Pharmacol. 63: 383-391. PMID: 12527810
5. Elzner, S., et al. 2008. ChemMedChem. 3: 924-939. PMID: 18366037

Appearance :
Crystalline
Physical State :
Solid
Derived From :
Penicillium
Solubility :
Soluble in methanol, dioxane, pyridine
Storage :
Store at -20° C
Melting Point :
204.78° C (Predicted)
Boiling Point :
~557.0° C at 760 mmHg (Predicted)
Density :
1.2 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
119418
Merck Index :
14: 2676
SMILES :
C[C@H]1CCCCCC(=O)C2=C(C=C(C=C2CC(=O)O1)O)O

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Certificate of Analysis

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