CTPB, an amide derivative also known as N-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxy-6-pentadecyl-benzamide, is an activator of p300 histone acetyltransferase (HAT) activity. HATs are groups of enzymes that play a important role in regulation of gene expression. This compound has been shown to enhance p300 HAT-dependent transcriptional activation in in vitro assembled chromatin templates. CTPB is membrane-impermeable and requires a carrier to enter cells.
1. Balasubramanyam, Karanam., et al., 2003. Small molecule modulators of histone acetyltransferase p300. The Journal of biological chemistry. 278(21): 19134-40. PMID: 12624111
2. Campo, Nathalie., et al., 2007. SpoIVB and CtpB are both forespore signals in the activation of the sporulation transcription factor sigmaK in Bacillus subtilis. Journal of bacteriology. 189(16): 6021-7. PMID: 17557826
3. Selvi, B Ruthrotha., et al., 2008. Intrinsically fluorescent carbon nanospheres as a nuclear targeting vector: delivery of membrane-impermeable molecule to modulate gene expression in vivo. Nano letters. 8(10): 3182-8. PMID: 18800851
4. Souto, José A., et al., 2010. New anacardic acid-inspired benzamides: histone lysine acetyltransferase activators. ChemMedChem. 5(9): 1530-40. PMID: 20683922
See how others have used CTPB. Click on the entry to view the PubMed entry .
PMID: # 26667266 Albrengues, J. et al. 2015. Nat Commun. 6: 10204.
PMID: # 25538147 Yao, XH. et al. 2014. Physiological reports. 2:
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