Cromolyn disodium salt A compound that blocks the release of pro-inflammatory mediators

Cromolyn disodium salt (CAS 15826-37-6)

Cromolyn disodium salt | CAS 15826-37-6 is rated 5.0 out of 5 by 1.
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Synonym: Cromoglycate; Cromoglycic acid
Application: A compound that blocks the release of pro-inflammatory mediators
CAS Number: 15826-37-6
Purity: ≥98%
Molecular Weight: 512.33
Molecular Formula: C23H14O112Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cromolyn disodium salt blocks the release of pro-inflammatory mediators, such as histamine, from mast cells.


References

Vural, K.M., et al., Effects of mast cell membrane stabilizing agents in a rat lung ischemia-reperfusion model. Ann. Thorac. Surg. 69, 228-232, (2000) Shishibori, et al., Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family. J. Biochem. 338, 583-589, (1999) Norris, A.A., Pharmacology of sodium cromoglycate. Clin. Exp. Allergy 26, 5-7, (1996)

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (100 mg/ml), DMSO (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Storage :
Desiccate at room temperature
Melting Point :
241-242° C (lit.)(dec.)
Refractive Index :
n20D ~1.68 (Predicted)
IC50 :
rat: IC50 = 0.74 µM; ALPPL2: IC50 = 9.68 mM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
DJ2380000
PubChem CID :
27503
Merck Index :
14: 2590
MDL Number :
MFCD00057744
EC Number :
239-926-7
Beilstein Registry :
3647577
SMILES :
C1=CC2=C(C(=C1)OCC(COC3=CC=CC4=C3C(=O)C=C(O4)C(=O)[O-])O)C(=O)C=C(O2)C(=O)[O-].[Na+].[Na+]

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Nurmatov et al Nurmatov et al. (PubMed iD 26095756) used Cromolyn disodium salt, an pro-inflammatory compound, to study antihistamine function in mast cell activation.
Date published: 2015-05-16
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