CP-55940 is a cannabimimetic small molecule and a potent cannabinoid receptor agonist, demonstrating similar binding activity at both receptor types (CB1 Ki=0.58 nM, CB2 Ki=0.69 nM). CP-55940 represents a useful non-selective agonist entry into the growing library of synthetic cannabimimetics, compounds which are being actively explored for efficacy in perturbing Alzheimer's disease and other neurodegenerative states.
1. Showalter, V.M., et al. 1996. J. Pharmacol. Exp. Ther. 278: 989-999. PMID: 8819477 2. Rinaldi-Carmona, M., et al. 1996. Life Sci. 58: 1239-1247. PMID: 8614277 3. Thomas, B.F., et al. 1998. J. Pharmacol. Exp. Ther. 285: 285-292. PMID: 9536023
Soluble in ethanol, DMSO and DMF all at ~30 mg/ml. Sparingly soluble in aqueous buffers, ethanol:PBS (1:3, pH 7.2, 0.25 mg/ml).
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Sparingly soluble in aqueous buffers, ethanol:PBS (1:3, pH 7.2, 0.25 mg/ml). Soluble in DMSO and DMF at 30 mg/ml.
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Rated 5 out of
Thomas et alThomas et al. (PubMed ID 9536023) found that CP-55,940 was a cannabinoid agonist that directly interacted with cannabinoid binding sites in the rat brain. -SCBT Publication Review
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