Coumermycin A1 An activator of JAK2 and Raf-1

Coumermycin A1 (CAS 4434-05-3)

Coumermycin A1 | CAS 4434-05-3 is rated 5.0 out of 5 by 1.
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Synonym: Notomycin
Application: An activator of JAK2 and Raf-1
CAS Number: 4434-05-3
Molecular Weight: 1110.08
Molecular Formula: C55H59N5O20
* Refer to Certificate of Analysis for lot specific data (including water content).
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Coumermycin A1, a cell permeable antibiotic, has been found to be a dimerizing agent that can activate a modified Raf-1 protein and stimulate the mitogen-activated protein kinase cascade. This compound has also been reported to induce autophosphorylation of GyrB-Janus Kinase (JAK) 2 fusion proteins, thus bypassing receptor activation. JAKs are cytoplasmic protein kinases that interact with intracellular domains of cytokine receptors which plays an important role in signal transduction. The activation of JAK is thought to induce cell proliferation. Studies suggest that Coumermycin A1 can inhibit the supercoiling activity of gyrase by binding to the gyrase B subunit.


References

1. Farrar, M.A. and Alberol-Ila, R.M. 1996. Nature. 383: 178-181. PMID: 8774884
2. Tsai, F.T., et al. 1997. Proteins. 28: 41-52. PMID: 9144789
3. Mizuguchi, R. and Hatakeyama, M. 1998. J. Biol. Chem. 273: 32297-32303. PMID: 9822709
4. Mohi, M.G., et al. 1998. Mol. Biol. Cell. 9: 3299-3308. PMID: 9843570

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mg/ml).
Storage :
Store at room temperature
Melting Point :
258-260° C (dec.)
Refractive Index :
n20D 1.68
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UX9375000
PubChem CID :
54678496
MDL Number :
MFCD00057312
Beilstein Registry :
470805
SMILES :
CC1=CC=C(N1)C(=O)OC2C(C(OC(C2OC)(C)C)OC3=C(C4=C(C=C3)C(=C(C(=O)O4)NC(=O)C5=CNC(=C5C)C(=O)NC6=C(C7=C(C(=C(C=C7)OC8C(C(C(C(O8)(C)C)OC)OC(=O)C9=CC=C(N9)C)O)C)OC6=O)O)O)C)O

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Certificate of Analysis

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Rated 5 out of 5 by from Various publications cite the use of Coumermycin Various publications cite the use of Coumermycin A1 to activate JAK2 and Raf-1. -SCBT Publication Review
Date published: 2015-02-04
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