CorticosteroneAn activator of MCRs and GRs

Corticosterone (CAS 50-22-6)

Corticosterone | CAS 50-22-6 is rated 5.0 out of 5 by 1.
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Synonym: Kendall's compound B; Reichstein's substance H; Coumpound B
Application: An activator of MCRs and GRs
CAS Number: 50-22-6
Molecular Weight: 346.46
Molecular Formula: C21H30O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Corticosterone is a hormone synthesized in response to stress. It binds and activates MCRs(mineralocorticoid receptors) and GRs (glucocorticoid receptors), which results in altered expression. This eventually affects ionic conductances through the membrane. Corticosterone induces apoptosis in murine bone marrow.


References

1. de Kloet, E.R. 1992. Ann. N. Y. Acad. Sci. 663: 357-371. PMID: 1336332
2. Joëls, M., et al. 1992. Trends Neurosci. 15: 25-30. PMID: 1374954
3. Garvy, B.A., et al. 1993. Immunology. 80: 587-592. PMID: 8307608

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in acetone, methanol, ethanol (10 mM), chloroform, and DMSO (100 mM). Insoluble in water.
Storage :
Store at room temperature
Melting Point :
179-183° C (lit.)
Boiling Point :
~529.25° C at 760 mmHg (Predicted)
Density :
~1.22 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
Optical Activity :
α20/D +223°±3°, c = 1 in ethanol
Ki Data :
Sigma opioid receptor: Ki= 35.6 µM (human)
pK Values :
pKa: 12.98 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GM7650000
PubChem CID :
5753
Merck Index :
14: 2538
MDL Number :
MFCD00037715
EC Number :
200-019-6
Beilstein Registry :
2339601
SMILES :
C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Taves et al Taves et al. (PubMed ID 26366679) found that Corticosterone produced by avian adrenals was necessary for adequate lymphocyte development in zebra finches. -SCBT Publication Review
Date published: 2015-06-27
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