Cordycepin

Cordycepin (CAS 73-03-0)

Cordycepin | CAS 73-03-0 is rated 4.0 out of 5 by 1.
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Synonym: 3'-Deoxyadenosine
Application: An anticancer, antifungal nucleoside analog
CAS Number: 73-03-0
Purity: ≥98%
Molecular Weight: 251.24
Molecular Formula: C10H13N5O3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cordycepin is a nucleoside analog that acts as an anticancer and antifungal agent. Cordycepin inhibits growth of various tumor cells in vitro. It can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Cordycepin is also useful for the study of messenger RNA transcription.


References

1. Gumport, R.I., et al. 1976. Biochemistry. 15: 2804-2809. PMID: 779831
2. Sugar, A.M., et al. 1998. Antimicrob. Agents Chemother. 42: 1424-1427. PMID: 9624488
3. Kodama, E.N., et al. 2000. Biochem. Pharmacol. 59: 273-281. PMID: 10609556

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), methanol, and water.
Storage :
Desiccate at 4° C
Melting Point :
225° C
Boiling Point :
~627.2° C at 760 mmHg (Predicted)
Density :
1.92 g/cm3 (Predicted)
Refractive Index :
n20D 1.86 (Predicted)
IC50 :
Vero: IC50 = 0.5 nM (Chlorocebus aethiops); Mitochondrial import inner membrane translocase subunit TIM23: IC50 = 14 µM (Saccharomyces cerevisiae S288c); Plasmodium falciparum: IC50 = 17.9 µM (Plasmodium falciparum K1); Hepatitis C virus NS5B RNA-dependent RNA polymerase: IC50 = 22 µM (Hepatitis C virus)
Ki Data :
Adenosine A1 receptor: Ki= 7.12 µM (rat)
pK Values :
pKa: 13.64 (Predicted), pKb: 3.82 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AU7358610
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
6303
Merck Index :
14: 2529
MDL Number :
MFCD00037998
EC Number :
200-791-4
Beilstein Registry :
35194
SMILES :
C1[C@H](O[C@H]([C@@H]1O)N2C=NC3=C2N=CN=C3N)CO

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Certificate of Analysis

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Cordycepin  Product Citations

See how others have used Cordycepin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 22910906  2012. J. Biol. Chem. 287: 34361-71.

Citations 1 to 1 of 1 total

What is the native source of the compound?

Asked by: two2igm05
Thank you for your question. Cordycepin (CAS 73-03-0) has a native source that is Ophiocordyceps sinensis.
Answered by: Technical Support
Date published: 2017-11-15
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Rated 4 out of 5 by from I will rate this product a 4 and rate 5 I will rate this product a 4 and rate 5 for your logistics, customer service and support.
Date published: 2015-04-20
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