Concanamycin A An inhibitor of vacuolar type H+-ATPase (V-ATPase)

Concanamycin A (CAS 80890-47-7)

Concanamycin A | CAS 80890-47-7 is rated 5.0 out of 5 by 2.
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Synonym: Folimycin; TAN 1323B
Application: An inhibitor of vacuolar type H+-ATPase (V-ATPase)
CAS Number: 80890-47-7
Purity: ≥99%
Molecular Weight: 866.08
Molecular Formula: C46H75NO14
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Concanamycin A, also designated folimycin, is an antibiotic and well-noted specific inhibitor of V-ATPase (vacuolar type H+-ATPase) activity. Concanamycin A is also capable of inducing cell-death through apoptosis, able to inhibit perforin-based cytotoxic activity in CD8+ T cells, and to inhibit intracellular protein trafficking in both plant and animal cells. As an inhibitor of V-ATPase, concanamycin has been reported to induce cell death via apoptosis in WEHI 231, SP2/0-Ag14 cells lines as well as mouse hybridomas. The inhibition of perforin-based cytotoxic activity in CD8+ CTL clone OE4 was reported to be selective for completely blocking perforin-based cytotoxic activity in these clones. Additionally, concanamycin A was noted to lead to reversible vacuolation of the Golgi apparatus in tobacco BY-2 cells, indicating potential interference with protein trafficking in this cell line.


References

1. Muroi, M., et al. 1993. Cell Struct. Funct. 18: 139-149. PMID: 8242793
2. Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 212: 255-262. PMID: 7612014
3. Kataoka, T., et al. 1996. J. Immunol. 156: 3678-3686. PMID: 8621902
4. Robinson, D.G., et al. 2004. Protoplasma. 224: 255-260. PMID: 15614486

Appearance :
Lyophilized powder
Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in water (partly), chloroform, ethanol, methanol, and DMSO.
Storage :
Store at -20° C
Boiling Point :
966.39° C at 760 mmHg (Predicted)
Density :
1.20 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
Ki Data :
V-ATPase : Ki= 0.02 nM
pK Values :
pKa: 12.46 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CB9732000
Transport :
UN 3462, Class 6.1, Packing group II
PubChem CID :
16211793
MDL Number :
MFCD00210037
Beilstein Registry :
3560277
SMILES :
CCC1C(C(C/C(=C/C=C/C(C(OC(=O)/C(=C/C(=C/C(C1O)C)/C)/OC)C(C)C(C(C)[C@@]2(C[C@H]([C@@H](C(O2)/C=C/C)C)O[C@H]3C[C@H]([C@@H]([C@H](O3)C)OC(=O)N)O)O)O)OC)/C)C)O

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Certificate of Analysis

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Concanamycin A  Product Citations

See how others have used Concanamycin A. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 18 total

PMID: # 28792845  Mishra, P. et al. 2017. Autophagy. 13: 1556-1572.

PMID: # 25999237  Li, Z. et al. 2016. Protoplasma. 253: 553-69.

PMID: # 27070082  Corcelle-Termeau, E. et al. 2016. Autophagy. 12: 833-49.

PMID: # 26984939  Li, DL. et al. 2016. Circulation. 133: 1668-87.

PMID: # 25681156  Munch, D. et al. 2015. The Plant cell. 27: 463-79.

PMID: # 25713383  Kanada, M. et al. 2015. Proc. Natl. Acad. Sci. U.S.A. 112: E1433-42.

PMID: # 25792726  Finelli, MJ. et al. 2015. Human molecular genetics. 24: 3529-44.

PMID: # 25561175  Rebsamen, M. et al. 2015. Nature. 519: 477-81.

PMID: # 26167652  Johnson, AE. et al. 2015. eLife. 4:

PMID: # 26352211  Pimentel-Elardo, SM. et al. 2015. ACS Chem. Biol. 10: 2616-23.

Citations 1 to 10 of 18 total

I just received the concA powder. it was shipped at room temperature, but it say to store it at -20. Is it normal? Thanks Carla

Asked by: Cb84
Thank you for your question. Concanamycin A (CAS 80890-47-7) sc-202111 is stable at ambient temperatures. While it is shipped at ambient temperatures it should be kept at -20 °C for long-term storage. Short-term exposure to ambient temperatures has no detrimental effect on the quality or the viability of Concanamycin A.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-14

Is this light sensitive?

Asked by: SCchem16
Thank you for your question. This chemical, Concanamycin A: sc-202111, is light sensitive and should be stored accordingly.
Answered by: Chemical Support 2
Date published: 2018-04-05

What temperature should I store at following reconstitution?

Asked by: SCchem16
Thank you for your question. This chemical, Concanamycin A (CAS 80890-47-7), when dissolved in chloroform, methanol, and ethanol should be prepared just before use. Solutions in DMSO can be stable for up to one year when stored at -20°C.
Answered by: Chemical Support 2
Date published: 2018-04-05
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Rated 5 out of 5 by from This chemical is working well in our experiments This chemical is working well in our experiments.
Date published: 2015-09-03
Rated 5 out of 5 by from No comment No comment.
Date published: 2015-03-26
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