Compound 15e is a potent and specific inhibitor of the PI 3-kinase p110α isoform. Compound 15e also inhibits proliferation of A375 melanoma cells (IC50 = 0.58 μM).
1. Hayakawa, M., et al. 2006. Bioorg. Med. Chem. 14: 6847-6858. PMID: 16837202
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