Colivelin is a neuroprotective peptide and activator of STAT3. It is able to protect neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. It also suppresses neuronal death by activating STAT3 in vitro; upregulates cholinergic transmission and improves memory impairment in Alzheimer's disease (AD) models.
SALLRSIPAPAGASRLLLLTGEIDLP; H - Ser - Ala - Leu - Leu - Arg - Ser - Ile - Pro - Ala - Pro - Ala - Gly - Ala - Ser - Arg - Leu - Leu - Leu - Leu - Thr - Gly - Glu - Ile - Asp - Leu - Pro - OH
Soluble in 30% acetonitrile / water (1 mg/ml).
Store at -20° C
1.42 g/cm3 (Predicted)
n20D 1.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Rated 5 out of
Induce RANKL expression in murine osteoblastsThis product (0.1 or 1.0 μM) induce RANKL expression in primary calvarial cells in mice. PLoS ONE 12(7):e0181126 · July 2017
Date published: 2017-08-04
Rated 5 out of
Wu et alWu et al. (PubMed ID 25332198) showed that colivelin (CLN) exhibited neurotprotective properties against the neurotoxic effects of Alzheimer s disease by inhibiting hippocampal A 25-35 in rats. -SCBT Publication Review
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