Colistin sulfate

Colistin sulfate (CAS 1264-72-8)

Colistin sulfate | CAS 1264-72-8 is rated 5.0 out of 5 by 1.
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Synonym: Belcomycin; Polymixin E Sulfate
Application: A Polymyxin potent antibiotic and apoptosis inducer
CAS Number: 1264-72-8
Purity: Mixture of >30 compounds, primarily colistin A and B
Molecular Weight: 1267.55
Molecular Formula: C53H102N16O17S
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Colistin sulfate, a cationic polypeptide from the polymyxin family, has been shown to be an extremely potent antibiotic that is effective against most gram-negative Bacilli. Mechanistic studies have reported that this compound induces apoptosis through interaction with the cytoplasmic membrane. Additional studies have demonstrated that Colistin sulphate is extremely toxic. Toxic effects noted include neurotoxicity, nephrotoxicity, vascular congestion of brain vessels, and extreme kidney and CNS negative effects.


References

1. David, H.L., et al. 1985. Antimicrob. Agents Chemother. 27: 701-707. PMID: 4015067
2. Evans, M.E., et al. 1999. Ann Pharmacother. 33: 960-967. PMID: 10492501
3. Landman, W.J., et al. 2000. Avian Pathol. 29: 593-601. PMID: 19184856
4. Beringer, P. 2001. Curr Opin Pulm Med. 7: 434-440. PMID: 11706322

Physical State :
Solid
Derived From :
Bacillus colistinus
Solubility :
Soluble in water (50mg/ml)
Storage :
Store at -20° C
Boiling Point :
1537.3° C
Refractive Index :
n20/D 1.575
Optical Activity :
α20/D -65°, c = 1 in water
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TR1500000
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
73090
Merck Index :
14: 2479
MDL Number :
MFCD00146495
EC Number :
215-034-3
SMILES :
CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O

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Certificate of Analysis

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Colistin sulfate  Product Citations

See how others have used Colistin sulfate. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27045615  Smith, KP. et al. 2016. Assay Drug Dev Technol. 14: 194-206.

Citations 1 to 1 of 1 total

Venden Colistin Sufato JP para la Indrustria Farmacéutica, concretamente para fabicar Gotas Oticas ?

Asked by: María Teresa Valencia M
Thank you for your question. No, our chemicals are for research use only. They are not intended for diagnostic or therapeutic use.
Answered by: Technical Support
Date published: 2018-03-05
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Rated 5 out of 5 by from Ashley Ashley, SL. et al. (PubMed 26378893) reported that targeting inhibitors of apoptosis protects from Belcomycin-induced lung fibrosis. -SCBT Publication Review
Date published: 2015-03-13
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