Colistin sodium methanesulfonate A cyclopolypeptide antibiotic and derivative of Polymyxin E

Colistin sodium methanesulfonate (CAS 8068-28-8)

Colistin sodium methanesulfonate | CAS 8068-28-8 is rated 5.0 out of 5 by 1.
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Synonym: Colimycin sodium methanesulfonate; Methanesulfonic acid derivative of Polymyxin E; Polymyxin E sodium methanesulfonate
Application: A cyclopolypeptide antibiotic and derivative of Polymyxin E
CAS Number: 8068-28-8
Molecular Weight: 1759.90
Molecular Formula: C58H115N16O28S55Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity. Antimicrobial spectrum: Gram-negative bacteria. Cyclopolypeptide antibiotic. Endotoxin-binding capacity.


References

1. M.J. Rogers, J. Cohen Infection (Munich) 14, 79, (1986)

Physical State :
Solid
Solubility :
Soluble in water (10 mg/ml).
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
GH1650000
PubChem CID :
16211791
Merck Index :
14: 2479
MDL Number :
MFCD00130824
EC Number :
232-516-9
SMILES :
CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)[C@@H](C)O.CS(=O)(=O)[O-].CS(=O)(=O)[O-].CS(=O)(=O)[O-].CS(=O)(=O)[O-].CS(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+]

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Certificate of Analysis

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Colistin sodium methanesulfonate  Product Citations

See how others have used Colistin sodium methanesulfonate. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27045615  Smith, KP. et al. 2016. Assay Drug Dev Technol. 14: 194-206.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Gregoire et al Gregoire et al. (PubMed ID 25267662) found that Colistin sodium methanesulfonate renal clearance and colistin concentrations at steady state are mostly governed by creatinine clearance. -SCBT Publication Review
Date published: 2015-03-23
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