Clotrimazole An antifungal compound and CYP inhibitor

Clotrimazole (CAS 23593-75-1)

Clotrimazole | CAS 23593-75-1 is rated 4.0 out of 5 by 2.
  • y_2019, m_4, d_20, h_3
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_3583, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 86ms
  • REVIEWS, PRODUCT
Synonym: 1-(o-Chlorotrityl)imidazole;1-(o-Chloro-α,α-diphenylbenzyl)imidazole
Application: An antifungal compound and CYP inhibitor
CAS Number: 23593-75-1
Purity: >98%
Molecular Weight: 344.843
Molecular Formula: C22H17ClN2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Clotrimazole is an imidazole derivative and an antifungal compound and a CYP (cytochrome P450) inhibitor. Clotrimazole has been shown to block the intermediate-conductance, IK1 channels (Ca2+ activated K+ channels), in cells such as erythrocytes. In vitro studies of various yeast strains have demonstrated susceptibility to clotrimazole. Clotrimazole is an activator of MB67 and an inhibitor of CYP3A4 and CYP51A1.


References

1. Sawyer, P.R., et al. 1975. Drugs. 9: 424-447. PMID: 1097234
2. Jensen, B.S., et al. 2001. Curr Drug Targets. 2: 401-422. PMID: 11732639
3. Carrillo-Muñoz, A.J., et al. 2002. Int. J. Antimicrob. Agents. 20: 375-379. PMID: 12431873

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (25 mM), chloroform (50 mg/ml), DMF, ethyl acetate, ethanol, methanol, and acetone.
Storage :
Store at room temperature
Melting Point :
144-151° C
Boiling Point :
482.30° C at 760 mmHg (Predicted)
Density :
1.14 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
Cytochrome P450 3A4: IC50 = 16 nM (human); Thromboxane-A synthase: IC50 = 14 nM (human); Cytochrome P450 19A1: IC50 = 1.8 nM (human); Plasmodium falciparum: IC50 = 60 nM; Plasmodium falciparum: EC5050 = 338 nM; ATP-dependent molecular chaperone HSP82: EC5050 = 133 nM (Candida albicans (strain WO-1) (Yeast)); Ca2+-activated K+ current: IC50 = 3 µM; Gardos channel: IC50 = 650 nM
Ki Data :
Dopamine D3 receptor: Ki= 899 nM (human); Muscarinic acetylcholine receptor M4: Ki= 1640 nM (human); Cytochrome P450 17A1: Ki= 81.5 nM (human); Delta opioid receptor: Ki= 1755 nM (human); Serotonin transporter: Ki= 3060 nM (human)
pK Values :
pKb: 6.12 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NI4377000
PubChem CID :
2812
Merck Index :
14: 2417
MDL Number :
MFCD00057220
EC Number :
245-764-8
Beilstein Registry :
622318
SMILES :
C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Clotrimazole  Product Citations

See how others have used Clotrimazole. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 18165236  Cifuentes, D. et al. 2008. J. Biol. Chem. 283: 5642-5649.

PMID: # 16527817  Li, H. et al. 2006. J. Biol. Chem. 281: 12546-12554.

PMID: # 15358766  Zhang, J. et al. 2004. J. Biol. Chem. 279: 49517-49522.

PMID: # 11679585  Gerbal-Chaloin, S. et al. 2002. J. Biol. Chem. 277: 209-217.

Citations 1 to 4 of 4 total

Can this product be used as a pharmaceutical standard?

Asked by: hanghang
Thank you for your question. No, this is research grade.
Answered by: Technical Support
Date published: 2019-01-26

solubility of clotomazole in ethanol

Asked by: mahmood hasan
Thank you for your question. sc-3583: clotomazole is soluble in ethanol at a concentration of > 65mg/mL.
Answered by: Technical Support
Date published: 2017-07-26

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-3583, is provided as a white to off-white crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-17
  • y_2019, m_4, d_20, h_3CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_3
  • loc_en_US, sid_3583, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 118ms
  • QUESTIONS, PRODUCT
Rated 3 out of 5 by from Does not seem to inhibit CYP3A4 Does not seem to inhibit CYP3A4
Date published: 2015-09-23
Rated 5 out of 5 by from Cifuentes Cifuentes, et. al. (PubMed ID 18165236) used clotrimazole in the course of their study regarding hepatic glycogen synthesis. Treated FTO2B cells with clotrimazole and observed no glycogen accumulation. -SCBT Publication Review
Date published: 2015-07-06
  • y_2019, m_4, d_20, h_3
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_3583, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 232ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.