Clinafloxacin A fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV

Clinafloxacin (CAS 105956-97-6)

Clinafloxacin | CAS 105956-97-6 is rated 5.0 out of 5 by 1.
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Synonym: 7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Application: A fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV
CAS Number: 105956-97-6
Purity: ≥95%
Molecular Weight: 365.8
Molecular Formula: C17H17ClFN3O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Clinafloxacin is a fluoroquinolone that inhibits both Topo II (DNA gyrase)and topoisomerase IV dually in Streptococcus pneumoniae. The compound has a broad-spectrum activity against gram-negative and gram-positive bacteria, aerobes and anaerobes. Studies comparing the inhibitory effects of the fluoroquinolones: clinafloxacin, trovafloxacin, sparfloxacin (sc-202343), and ciprofloxacin (sc-29064) demonstrated clinafloxacin having the greatest inhibition of Topo II (DNA gyrase) and topoisomerase IV.


References

1. Pan, X.S., et al. 1998. Antimicrob. Agents Chemother. 42: 2810-2816. PMID: 9797208
2. Pan, X.S., et al. 1999. Antimicrob. Agents Chemother. 43: 1129-1136. PMID: 10223925
3. Jorgensen, J.H., et al. 2000. Antimicrob. Agents Chemother. 44: 2962-2968. PMID: 11036007
4. Fernandez-Moreira, E., et al. 2000. Microb. Drug Resist. 6: 259-267. PMID: 11272253

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water.
Storage :
Store at -20° C
Melting Point :
~253° C
Boiling Point :
592.26° C at 760 mmHg (Predicted)
Density :
1.57 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
Streptokinase A: EC5050 = 64 nM (Streptococcus pyogenes serotype M1); Streptococcus sp. 'group A': EC5050 = 115 nM (Streptococcus sp. 'group A'); Streptococcus: EC5050 = 142 nM (Streptococcus); DNA gyrase: IC50 = 0.55 µM (Escherichia coli K-12); V79: IC50 = 71.08 µM (hamster)
pK Values :
pKa: 6.39 (Predicted), pKb: 9.1 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
VB1800600
PubChem CID :
60063
Merck Index :
14: 2355
MDL Number :
MFCD00865120
SMILES :
C1CC1N2C=C(C(=O)C3=CC(=C(C(=C32)Cl)N4CCC(C4)N)F)C(=O)O

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Clinafloxacin  Product Citations

See how others have used Clinafloxacin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25881748  Tang Girdwood, SC. et al. 2015. Biochem. Pharmacol. 95: 227-37.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Fernandez Fernandez-Moreira et al. (PubMed ID 11272253) found that clinafloxacin inhibited topoisomerase iV and gyrase in S. pneumoniae. -SCBT Publication Review
Date published: 2015-03-11
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