Ciprofloxacin A fluorinated quinolone antibacterial

Ciprofloxacin (CAS 85721-33-1)

Ciprofloxacin | CAS 85721-33-1 is rated 5.0 out of 5 by 1.
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Synonym: Cipro IV; 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid
Application: A fluorinated quinolone antibacterial
CAS Number: 85721-33-1
Purity: ≥98%
Molecular Weight: 331.34
Molecular Formula: C17H18FN3O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ciprofloxacin is a fluorinated quinolone antibacterial.


References

Hoffken, G., et al.: Antimicrob. Ag. Chemother., 27, 375 (1985) Scully, B.E., et al.: Lancet, 1, 819 (1986)

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (<1 mg/ml at 25° C), methanol, 0.1N hydrochloric acid (25 mg/ml), and ethanol (<1 mg/ml at 25° C). Insoluble in water.
Storage :
Store at room temperature
Melting Point :
253-257° C
Boiling Point :
~581.8° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
Escherichia coli: IC50 = 9.05 nM; Staphylococcus aureus: IC50 = 0.15 µM; Topo IIβ: IC50 = 0.60 µM (human); Mycobacterium intracellulare: IC50 = 0.75 µM; DNA gyrase: IC50 = 2.05 µM (Escherichia coli K-12)
Ki Data :
Histamine H3 receptor: Ki= 0.65 nM (rat); HERG: Ki>100 µM (human)
pK Values :
pKa: 6.43 (Predicted), pKb: 8.68 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
VB1993800
PubChem CID :
2764
Merck Index :
14: 2314
MDL Number :
MFCD00185755
Beilstein Registry :
3568352
SMILES :
C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O

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Certificate of Analysis

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Ciprofloxacin  Product Citations

See how others have used Ciprofloxacin. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 26064137  Heger, Z. et al. 2015. Electrophoresis. 36: 1256-64.

PMID: # 26121981  Yin, J. et al. 2015. Brain. 138: 2553-70.

PMID: # 24602972  Lee, SH. et al. 2014. Biochimica et biophysica acta. 1839: 374-86.

PMID: # 23747342  Villalpando Rodriguez, GE. et al. 2013. Biochim. Biophys. Acta. 1833: 2244-53.

PMID: # 18765414  Cao, G. et al. 2008. J. Antimicrob. Chemother. 62: 1009-14.

Citations 1 to 5 of 5 total
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Rated 5 out of 5 by from Xu Xu, B. et al. (PubMed 26339360) found that simulated microgravity affected Ciprofloxacin, a fluoroquinolone antibacterial, susceptibility and upregulated acrAB-tolC gene expression in E.coli ATCC25922. -SCBT Publication Review
Date published: 2015-07-01
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