Ciprofibrate Ciprofibrate is a hypolipidemic compound that can induce proliferation of peroxisomes in liver cells of rats. PPARα (peroxisome proliferator-activated receptor α) agonist.

Ciprofibrate  (CAS 52214-84-3)

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Application: A hypolipidemic agonist of PPARα
CAS Number: 52214-84-3
Purity: ≥98%
Molecular Weight: 289.2
Molecular Formula: C13H14Cl2O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Ciprofibrate sc-204689 25 mg $50.00
Ciprofibrate sc-204689A 100 mg $163.00

Ciprofibrate is a hypolipidemic compound that can induce proliferation of peroxisomes in liver cells of rats. Known to be a PPARα (peroxisome proliferator-activated receptor α) agonist.


References

Comparison of the effects of various peroxisome proliferators on peroxisomal enzyme activities, DNA synthesis, and apoptosis in rat and human hepatocyte cultures: V. Goll, et al.; Toxicol. Appl. Pharmacol. 160, 21 (1999) Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate: P. Passilly, et al.; Biochem. Pharmacol. 58, 1001 (1999) Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate: M.C. Clemencet, et al.; Cancer Lett. 222, 217 (2005) P450 CYP2C epoxygenase and CYP4A w-hydroxylase mediate ciprofibrate-induced PPARa-dependent peroxisomal proliferation: A. Gatica, et al.; J. Lipid Res. 48, 924 (2007) Lalwani ND, Reddy MK, Qureshi SA et al. Hum Toxicol. 2:27-48 (1983). Clemencet MC, Muzio G, Trombetta A et al. Cancer Lett. 222:217-226 (2005).

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (<1 mg/ml at 25° C), chloroform (miscible), acetone (miscible), ethanol (58 mg/ml at 25° C), and DMSO (58 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
114-116° C
Boiling Point :
~424.9° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
PPARα: EC5050 = 0.9 µM (human); PPARα: EC5050 >10 µM (rat)
pK Values :
pKa: 3.31 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UF0880000
PubChem CID :
2763
Merck Index :
14: 2313
MDL Number :
MFCD00467135
EC Number :
257-744-6
Beilstein Registry :
1984981
SMILES :
CC(C)(OC1=CC=C(C=C1)C1CC1(Cl)Cl)C(O)=O

Download SDS (MSDS)

Certificate of Analysis

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