Cinoxacin An antibacterial quinolone

Cinoxacin (CAS 28657-80-9)

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Synonym: Cinoxacino; Cinoxacinum; Clinoxacin
Application: An antibacterial quinolone
CAS Number: 28657-80-9
Purity: ≥99%
Molecular Weight: 262.22
Molecular Formula: C12H10N2O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cinoxacin is an antibacterial quinolone analog of oxolinic acid. The compound has been documented to block DNA synthesis through inhibition of Topo II (DNA gyrase) as well as topoisomerase IV. Cinoxacin has been observed to block both topoisomerse IV in both prokaryotic and eukaryotic cell lines. Due to the inhibiting activity of Cinoxacin the compound has displayed toxicity against eukaryotic cells. In vitro studies have shown the renal damage caused by Cinoxacin to be attributed to deposition of Cinoxacin crystals in the urinary tract.


References

1. Sisca, T.S., et al. 1983. Drugs. 25: 544-569. PMID: 6347618
2. Drlica, K. and Zhao, X. 1997. Microbiol. Mol. Biol. Rev. 61: 377-392. PMID: 9293187

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in alka line solutions (pH 10 or more), and most polar organic solvents.. Insoluble in water.
Storage :
Store at 4° C
Melting Point :
261-262° C
Boiling Point :
517.2° C at 760 mmHg (Predicted)
Density :
1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.71 (Predicted)
IC50 :
DNA gyrase: IC50 >262.22 nM (Escherichia coli K-12); Plasmodium falciparum 3D7: IC50 = 5.01 µM; Plasmodium falciparum: IC50 = 6.31 µM; PhoP regulon: IC50 = 27.94 µM (Salmonella Typhimurium)
pK Values :
pKb: 4.33 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
JI4640000
PubChem CID :
2762
Merck Index :
14: 2309
MDL Number :
MFCD00056776
EC Number :
249-133-8
Beilstein Registry :
1084304
SMILES :
CCN1C2=CC3=C(C=C2C(=O)C(=N1)C(=O)O)OCO3

Download SDS (MSDS)

Certificate of Analysis

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