Cinnamycin (lanthiopeptin) is a high molecular weight tricyclic antibiotic produced by several species of Streptoverticillium. Cinnamycin is a potent indirect inhibitor of PLA2 (phospholipase A2), acting by specifically sequestering phosphatidylethanolamine (PE), a major component of the mammalian plasma cell membrane. Cinnamycin induces trans-bilayer phospholipid movement in cell membranes to expose internally bound PE. At high surface concentrations of PE, cinnamycin induces membrane re-organization including membrane fusion and alteration of gross morphology.
Soluble in DMSO (10 mg/ml), DMF, methanol, ethanol, and water (poorly).
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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