Cinnamtannin B-1 is an A-type proanthocyanidin contained in several plant species such as Laurus nobilis L., Vaccinium vitis-idaea, Parameria laevigata, Cinnamomum zeylanicum and Lindera umbellata. Cinnamtannin B-1 is a potent antioxidant and protective agent against oxidative stress and apoptosis in human platelets. Cinnamtannin B-1 is a Cox-2 (cyclooxygenase-2) inhibitor.
1. Ezaki, N., et al. 1985. Planta Med. 51: 34-38. PMID: 17340396 2. Kashiwada,Y., et al. 1992. J. Nat. Prod. 55: 1033-1043. PMID: 1431932 3. Ho, K.Y., et al. 1999 J. Pharm. Pharmacol. 51: 1075-1078. PMID: 10528992 4. Kamiya, K., et al. 2001. Chem. Pharm. Bull. 49: 551-557. PMID: 11383605 5. Taher, M., et al .2004. Med. J. Malaysia. 59: 97-98. PMID: 15468836 6. Jayaprakasha, G.K., et al. 2006. J. Agric. Food Chem. 54: 1672-1679. PMID: 16506818 7. Ben Amor, N., et al. 2007. J. Med. Chem. 50: 3937-3944. PMID: 17602466 8. Bouaziz, A., et al. 2007. Apoptosis. 12: 489-498. PMID: 17195094 9. Bouaziz, A., et al. 2007. Arch. Biochem. Biophys. 457: 235-242. PMID: 17118329 10. López, J.J., et al. 2008. Life Sci. 82: 977-982. PMID: 18433795
Laurus nobilis L.
Soluble in 100% ethanol, methanol, and a mixture of DMSO and water.
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Lopez et alLopez et al. (Pubmed ID 18433795) showed that Cinnamtannin B-1 is an effective antioxidant and platelet aggregation inhibitor that works by preventing endogenous ROS generation. -SCBT Publication Review
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