Cinnamtannin B-1 A potent antioxidant and Cox-2 inhibitor

Cinnamtannin B-1 (CAS 88082-60-4)

Cinnamtannin B-1 | CAS 88082-60-4 is rated 5.0 out of 5 by 1.
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Synonym: Epicatechin-(4β→8,2β→O→7)-epicatechin-(4α→8)-epicatechin
Application: A potent antioxidant and Cox-2 inhibitor
CAS Number: 88082-60-4
Purity: ≥90%
Molecular Weight: 864.75
Molecular Formula: C45H36O18
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cinnamtannin B-1 is an A-type proanthocyanidin contained in several plant species such as Laurus nobilis L., Vaccinium vitis-idaea, Parameria laevigata, Cinnamomum zeylanicum and Lindera umbellata. Cinnamtannin B-1 is a potent antioxidant and protective agent against oxidative stress and apoptosis in human platelets. Cinnamtannin B-1 is a Cox-2 (cyclooxygenase-2) inhibitor.


References

1. Ezaki, N., et al. 1985. Planta Med. 51: 34-38. PMID: 17340396
2. Kashiwada,Y., et al. 1992. J. Nat. Prod. 55: 1033-1043. PMID: 1431932
3. Ho, K.Y., et al. 1999 J. Pharm. Pharmacol. 51: 1075-1078. PMID: 10528992
4. Kamiya, K., et al. 2001. Chem. Pharm. Bull. 49: 551-557. PMID: 11383605
5. Taher, M., et al .2004. Med. J. Malaysia. 59: 97-98. PMID: 15468836
6. Jayaprakasha, G.K., et al. 2006. J. Agric. Food Chem. 54: 1672-1679. PMID: 16506818
7. Ben Amor, N., et al. 2007. J. Med. Chem. 50: 3937-3944. PMID: 17602466
8. Bouaziz, A., et al. 2007. Apoptosis. 12: 489-498. PMID: 17195094
9. Bouaziz, A., et al. 2007. Arch. Biochem. Biophys. 457: 235-242. PMID: 17118329
10. López, J.J., et al. 2008. Life Sci. 82: 977-982. PMID: 18433795

Physical State :
Solid
Derived From :
Laurus nobilis L.
Solubility :
Soluble in 100% ethanol, methanol, and a mixture of DMSO and water.
Storage :
Store at -20° C
Density :
~1.8 g/cm3 (Predicted)
Refractive Index :
n20D 1.84 (Predicted)
IC50 :
HIV: IC50 = >25 µM (human); Bacillus stearothermophilus alpha glucosidase-4: IC50 = >100 µM (Geobacillus stearothermophilus)
pK Values :
pKa: 8.75 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
475277
SMILES :
C1[C@H]([C@H](OC2=C1C(=CC(=C2[C@@H]3[C@H]([C@H](OC4=C5[C@@H]6[C@H]([C@@](OC7=CC(=CC(=C67)O)O)(OC5=CC(=C34)O)C8=CC(=C(C=C8)O)O)O)C9=CC(=C(C=C9)O)O)O)O)O)C1=CC(=C(C=C1)O)O)O

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Certificate of Analysis

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Rated 5 out of 5 by from Lopez et al Lopez et al. (Pubmed ID 18433795) showed that Cinnamtannin B-1 is an effective antioxidant and platelet aggregation inhibitor that works by preventing endogenous ROS generation. -SCBT Publication Review
Date published: 2015-06-13
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