Cilastatin sodium A dipeptidase inhibitor with nephroprotective effects

Cilastatin sodium (CAS 81129-83-1)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 65ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: [R-[R*,S*-(Z)]]-7-[(2-Amino-2-carboxyethyl)thio]-2- [[(2,2-dimethylcyclopropyl)carbonyl]amino]-2- heptenoic acid monosodium salt
Application: A dipeptidase inhibitor with nephroprotective effects
CAS Number: 81129-83-1
Purity: ≥98%
Molecular Weight: 380.43
Molecular Formula: C16H25N2O5S•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Cilastatin is a dipeptidase inhibitor that specifically inhibits DPEP1 (dehydrodipeptidase I), a renal membrane-bound glycoprotein involved in the hydrolytic metabolism of penem and carbapenem β-lactam antibiotics. Cilastatin has been shown to inhibit leukotriene D4 hydrolase in porcine kidney microvillar membranes which inhibits the conversion of leukotriene D4 to leukotriene E4. Also, Cilastatin has been used to maintain the antibiotic activity of imipenem (sc-205350) through inhibiting dipeptidase activity. It has been reported that Cilastatin exhibits nephroprotective effects in cyclosporine A-induced nephrotoxicity in kidney proximal tubule epithelial cells and inhibits the bacterial metallo-β-lactamase, an enzyme responsible for bacterial resistance to β-lactam antibiotics.


References

1. Keynan, S., et al. 1995. Antimicrob. Agents Chemother. 39: 1629-1631. PMID: 7492120
2. Yamaya, M., et al. 1998. Respir Physiol. 111: 101-109. PMID: 9496476
3. White, I.J., et al. 1999. Anal. Biochem. 268: 245-251. PMID: 10075814
4. Nitanai, Y., et al. 2002. J. Mol. Biol. 321: 177-184. PMID: 12144777
5. Tejedor, A., et al. 2007. Curr Med Res Opin. 23: 505-513. PMID: 17355732
6. Jia, B., et al. 2010. Chemotherapy. 56: 285-290. PMID: 20714145
7. Camano, S., et al. 2010. J. Pharmacol. Exp. Ther. 334: 419-429. PMID: 20435919
8. Zilberberg, M.D., et al. 2010. Surg Infect. PMID: 20666580

Physical State :
Solid
Solubility :
Soluble in water (25 mg/mL), DMSO (10 mg/mL), and methanol.
Storage :
Store at -20° C
Ki Data :
LTDase: Ki= 0.11 µM; leukotriene D4 hydrolase: Ki= 0.11 µM; dehydropeptidase I: Ki= 0.11 µM
pK Values :
pKa: 2.0, 4.4, 9.2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
MJ9650200
PubChem CID :
23663403
EC Number :
279-694-4
SMILES :
CC1(C[C@@H]1C(=O)N/C(=C\CCCCSC[C@@H](C(=O)O)N)/C(=O)[O-])C.[Na+]

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 56ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 44ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.