CIL-102 is a semisynthetic alkaloid derivative, which inhibits cell growth in a wide variety of cancer cell lines in a dose dependent manner. Studies conducted with Immunofluorescence microscopy suggest that CIL-102 can functions to slow down cell growth by binding to Tubulin, inhibiting Tubulin polymerization and disrupting microtubule organization. In addition, cells accumulate in the presence of CIL-102 in G(2)/M phase and sub-G(0)/G(1) phase. CIL-102 causes apoptosis in PC-3 cells via activation of caspase-3 and slows down cell growth by modulating cyclin-dependent kinases.
1. Huang, Y.T., et al. 2005. J. Biol. Chem. 280: 2771-2779. PMID: 15536083
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