Ciglitazone An inhibitor of HUVEC differentiation and angiogenesis that stimulates adipogenesis

Ciglitazone (CAS 74772-77-3)

Ciglitazone | CAS 74772-77-3 is rated 5.0 out of 5 by 1.
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Synonym: U-63287
Application: An inhibitor of HUVEC differentiation and angiogenesis that stimulates adipogenesis
CAS Number: 74772-77-3
Purity: ≥98%
Molecular Weight: 333.44
Molecular Formula: C18H23NO3S
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Ciglitazone is an antihyperglycemic agent of the thiazolidinedione structural class. It displays antihyperglycemic activity in genetically obese C57 Bl/6 ob/ob mice and is a selective PPARγ agonist (EC50=3 μM). Ciglitazone inhibits HUVEC differentiation and angiogenesis and also stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells. This compound is at least 33-fold selective over PPARα and δ.


References

1. Sohda, T., et al. 1982. Chem. Pharm. Bull. 30: 3580-3600. PMID: 7160012
2. Clark, D.A., et al. 1991. J. Med. Chem. 34: 319-325. PMID: 1992133
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7. Benvenuti, S., et al. 2007. J. Endocrinol. Invest. 30: RC26-RC30. PMID: 17993761

Usage :
Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Physical State :
Solid
Solubility :
Soluble in DMSO (>25 mg/ml), 100% ethanol (>25 mg/ml), 1eq. NaOH (100 mM), DMF (~16 mg/ml), 1:4 solution of DMSO:PBS (pH 7.2) (~400 µg/ml), and water (400 µg/ml) at 25° C.
Storage :
Store at 4° C
Melting Point :
251.08° C (Predicted)
Boiling Point :
~504.5° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
PPARγ ligand-binding domain: EC5050 = 3.0 µM; Monoamine oxidase B: IC50 = 225 nM (human)
pK Values :
pKa: 6.36 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
XJ5813700
PubChem CID :
2750
MDL Number :
MFCD00865499
SMILES :
CC1(CCCCC1)COC2=CC=C(C=C2)CC3C(=O)NC(=O)S3

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Certificate of Analysis

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Ciglitazone  Product Citations

See how others have used Ciglitazone. Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 20093366  Wei, S. et al. 2010. J. Biol. Chem. 285: 9780-9791.

PMID: # 16711003  Zhang, W. et al. 2006. J. Huazhong Univ. Sci. Technol. Med. Sci. 26: 36-39.

PMID: # 15699354  Kolluri SK et al. 2005. Proc. Natl. Acad. Sci. USA. 102(7): 2525-2530.

PMID: # 12421816  Dang, ZC. et al. 2003. J. Biol. Chem. 278: 962-967.

PMID: # 11590167  Fu, M. et al. 2001. J. Biol. Chem. 276: 45888-45894.

PMID: # 10358062  Morrison, R.F. et al. 1999. J. Biol. Chem. 274: 17088-17097.

PMID: # 8505086  Pershadsingh, HA. et al. 1993. Hypertension. 21: 1020-1023.

PMID: # 3689881  Thurlby, PL. et al. 1987. Biosci. Rep. 7: 573-577.

Pan, H et al. The Chinese-German Journal of Clinical Oncology.

Citations 1 to 9 of 9 total
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Rated 5 out of 5 by from Wei Wei, et. al. (PubMed ID 20093366) that ciglitazone was able to evoke a cellular response of energy restriction in LNCaP prostate cancer and MCF-7 breast cancer cells. -SCBT Publication Review
Date published: 2015-06-06
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