Chrysophanol An inducer of intracellular Ca2+ concentration and exhibit antifungal activities

Chrysophanol (CAS 481-74-3)

Chrysophanol | CAS 481-74-3 is rated 5.0 out of 5 by 1.
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Synonym: Chrysophanic acid; 1,8-Dihydroxy-3-methylanthraquinone
Application: An inducer of intracellular Ca2+ concentration and exhibit antifungal activities
CAS Number: 481-74-3
Purity: ≥98%
Molecular Weight: 254.24
Molecular Formula: C15H10O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Chrysophanol is an anthraquinone found in the root of Rheum wittrochii. It has been shown to increase intracellular Ca2+ concentration and exhibit antifungal activities.


References

1. Kuo, Y.C., et al. 1997. Life Sci. 61: 2335-2344. PMID: 9408056
2. Agarwal, S.K., et al. 2000. J. Ethanopharmacol. 72: 43-46. PMID: 10967452

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in chloroform, ether, DMSO ( at 25° C), and ethanol ( at 25° C). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
195° C
Boiling Point :
~489.50° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.71 (Predicted)
IC50 :
HIV-1(RF): IC50 >28.4 µM (CEM); HIV-1(RF): EC5050 >28.4 µM (CEM); HIV PROMOTER: IC50 >100 µg/ml (HIV-1)
pK Values :
pKa: 6.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CB6725000
PubChem CID :
10208
Merck Index :
14: 2258
MDL Number :
MFCD00001208
EC Number :
207-572-2
Beilstein Registry :
1252300
SMILES :
CC1=CC(=C2C(=C1)C(=O)C3=C(C2=O)C(=CC=C3)O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Lin et al Lin et al. (PubMed ID 26064235) found that chrysophanol had an antioxidant and anti-inflammatory effect by attenuating radical-mediated oxidative damage in BV2 murine microglia. -SCBT Publication Review
Date published: 2015-04-20
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