Chromomycin A3 A G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye

Chromomycin A3 (CAS 7059-24-7)

Chromomycin A3 | CAS 7059-24-7 is rated 5.0 out of 5 by 1.
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Application: A G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye
CAS Number: 7059-24-7
Purity: ≥97%
Molecular Weight: 1183.25
Molecular Formula: C57H82O26
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Chromomycin A3, a fluorescent DNA stain and antibiotic, has been reported to strongly inhibit zinc-dependent transcriptional activity of sheep Metallothionein 1A promoter in reporter gene assays of transfected cells. This compound has also been shown to be a potent inhibitor of neuronal apoptosis induced by glutathione depletion-induced oxidative stress and DNA-damaging agent Camptothecin (sc-200871). Mechanistic studies suggest that Chromomycin A3 antagonizes enhanced DNA binding of the transcription factors Sp1 and Sp3 to their cognate "G-C" box, induced by oxidative stress or DNA damage. Furthermore, by inhibiting transcription, Chromomycin A3 and its structural analogs can inhibit protein biosynthesis.


References

1. Jeon, C.J., et al. 1993. J. Histochem. Cytochem. 41: 1651-1658. PMID: 8409373
2. Wong, S.S., et al. 1994. Biochem. Pharmacol. 47: 827-837. PMID: 7510966
3. Chatterjee, S., et al. 2001. Ann. Neurol. 49: 345-354. PMID: 11261509
4. Mir, M.A., et al. 2003. Bioorg. Med. Chem. 11: 2791-2801. PMID: 12788353
5. Hoyos, P., et al. 2010. Acc. Chem. Res. 43: 288-299. PMID: 19908854

Physical State :
Solid
Derived From :
Streptomyces griseus
Solubility :
Soluble in ethanol, DMSO, and ethyl acetate (10 mg/ml).
Storage :
Store at -20° C
Melting Point :
185° C (dec.)
Refractive Index :
n20D 1.62
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GB7875000
PubChem CID :
5179132
Merck Index :
14: 2238
MDL Number :
MFCD00043151
EC Number :
230-348-0
SMILES :
CC1C(C(CC(O1)OC2C(CC3=C(C2=O)C(=C4C(=C3)C=C(C(=C4O)C)OC5CC(C(C(O5)C)OC(=O)C)OC6CC(C(C(O6)C)OC)O)O)C(C(=O)C(C(C)O)O)OC)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)OC(=O)C)(C)O)O

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Rated 5 out of 5 by from Mir et al Mir et al. (PubMed ID 12788353) used chromomycin A3 to inhibit protein biosynthesis via transcription inhibition by interfering with Mg2+/chromatin complexes in rat liver cells. -SCBT Publication Review
Date published: 2015-06-13
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