CHPGA selective mGluR-5 agonist

CHPG (CAS 170846-74-9)

CHPG | CAS 170846-74-9 is rated 5.0 out of 5 by 1.
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Synonym: α-Amino-2-chloro-5-hydroxybenzeneacetic acid; (RS)-2-Chloro-5-hydroxyphenylglycine
Application: A selective mGluR-5 agonist
CAS Number: 170846-74-9
Molecular Weight: 201.61
Molecular Formula: C8H8NO3Cl
* Refer to Certificate of Analysis for lot specific data (including water content).
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CHPG is a selective metabotropic glutamate receptor agonist, mGluR-5. CHPG is inactive at mGluR-1a which is expressed in CHO cells.


References

1. Doherty, A.J., et al. 1997. Neuropharmacology. 36: 265-267. PMID: 9144665
2. Salt, T.E., et al. 1999. Br. J. Pharmacol. 127: 1057-1059. PMID: 10455248
3. Bao, W.L., et al. 2001. Brain Res. 922: 173-179. PMID: 11743947

Physical State :
Solid
Solubility :
Soluble in DMSO (≥10 mg/ml), and 1.1eq. NaOH (100 mM). Insoluble in water.
Storage :
Desiccate at 4° C
Melting Point :
273.37° C (Predicted)
Boiling Point :
~407.3° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
mGluR-5: EC5050 = 750 µM
pK Values :
pKa: 1.61 (Predicted), pKb: 9.82 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
3645780
MDL Number :
MFCD01321059
SMILES :
C1=CC(=C(C=C1O)C(C(=O)O)N)Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Salt et al Salt et al. (PubMed ID 10455248) showed that CHPG, a mGlu5 agonist, induced excitatory responses of single rat thalamic neurons. -SCBT Publication Review
Date published: 2015-05-25
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