Cholic acid A non-denaturing ionic detergent

Cholic acid (CAS 81-25-4)

Cholic acid | CAS 81-25-4 is rated 5.0 out of 5 by 1.
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Synonym: 3α,7α,12α-Trihydroxy-5β-cholanic acid; Cholanic acid
Application: A non-denaturing ionic detergent
CAS Number: 81-25-4
Molecular Weight: 408.57
Molecular Formula: C24H40O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cholic acid, non-denaturing ionic detergent used for extraction of membrane proteins. Bile Acid

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in alcohols, acetone, DMSO, methanol, and water (slightly).
Storage :
Store at 4° C
Melting Point :
200-201° C (lit.)
Boiling Point :
~583.9° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
Optical Activity :
α20/D 35.5°±2.5°, c = 2 in ethanol
IC50 :
TGR5: IC50 = 5.3 µM (mouse); TGR5: IC50 = 6 µM (human); HCT-116: IC50>50 µM (human); MCF7: IC50 = 50 µM (human); GBM: IC50>50 µM (human)
pK Values :
pKa: 4.98(20° C)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
FZ9350000
PubChem CID :
221493
Merck Index :
14: 2203
MDL Number :
MFCD00003672
EC Number :
201-337-8
Beilstein Registry :
2822009
SMILES :
C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Reich Reich, et al. (PubMed ID 26420419) studied bile acid (BA) dependent cholangiocyte proliferation in TGR5 Knockout and wild type mice after being fed a cholic acid diet and under going common bile duct ligation (CBDL). -SCBT Publication Review
Date published: 2015-02-01
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