Chlortetracycline hydrochloride A specific and potent calcium ionophore antibiotic

Chlortetracycline hydrochloride (CAS 64-72-2)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 10ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: Aureomycin HCI; Auxeomycin; Isphamycin
Application: A specific and potent calcium ionophore antibiotic
CAS Number: 64-72-2
Purity: ≥80%
Molecular Weight: 515.34
Molecular Formula: C22H23ClN2O8•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Chlortetracycline Hydrochloride is a specific and potent calcium ionophore antibiotic. The compound has been shown to inhibit binding of aminoacyl-tRNA to ribosomes. In endoplasmic reticulum studies Chortetracycline has been used as a fluorescent dye to analyze calcium changes during apotosis, and in other processes. Chlortetracycline has been shown to block platelet secretion and can affect 17β-estradiol (E2) synthesis in H295R cells. Kupffer cell studies have shown that Chlortetracycline can inhibit secretion of TNF α. We offer the Chlortetracycline Hydrochloride form.


References

1. Wurmbach, P., et al. 1979. Proc. Natl. Acad. Sci. U.S.A. 76: 2143-2147. PMID: 221915
2. White, J.R. and Pearce, F.L. 1982. Biochemistry. 21: 6309-6312. PMID: 7150561
3. Mürer, E.H. and Siojo, E. 1982. Thromb. Haemost. 47: 62-65. PMID: 6803382
4. Oliver, A.E., et al. 2000. Biophys. J. 78: 2116-2126. PMID: 10733989
5. Akunda, J.K., et al. 2001. Comp. Immunol. Microbiol. Infect. Dis. 24: 81-89. PMID: 11247048
6. Gillan, L., et al. 2005. Theriogenology. 63: 445-457. PMID: 15626410
7. Cerella, C., et al. 2007. Ann. N.Y. Acad. Sci. 1099: 490-493. PMID: 17446492
8. Ji, K., et al. 2010. J. Hazard. Mater. 182: 494-502. PMID: 20630653

Appearance :
Powder
Physical State :
Solid
Derived From :
Isolated from Streptomyces aureofaciens.
Solubility :
Soluble in water (~8.6 mg/mL), methanol (~17.4 mg/mL), ethanol (~1.7 mg/mL), 1 M NaOH (50 mg/mL), and DMSO.
Storage :
Store at -20° C
Melting Point :
210-215° C (lit.)(dec.)
Refractive Index :
n20D ~1.74 (Predicted)
Optical Activity :
α20/D -242.5°, c = 0.5 in water
pK Values :
pKa: 3.3, 7.4, 9.3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
QI7800000
PubChem CID :
5483150
Merck Index :
14: 2192
MDL Number :
MFCD00082440
EC Number :
200-591-7
Beilstein Registry :
3858364
SMILES :
CC1(C2CC3C(C(=O)C(=C(N)O)C(=O)C3(C(=O)C2=C(C4=C(C=CC(=C41)Cl)O)O)O)N(C)C)O.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 54ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 47ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.