Chlorothricin A spirotetronic acid antibiotic inhibitor of pyruvate carboxylase

Chlorothricin (CAS 34707-92-1)

Chlorothricin | CAS 34707-92-1 is rated 5.0 out of 5 by 1.
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Synonym: K-818A
Application: A spirotetronic acid antibiotic inhibitor of pyruvate carboxylase
CAS Number: 34707-92-1
Purity: >99%
Molecular Weight: 955.48
Molecular Formula: C50H63CIO16
* Refer to Certificate of Analysis for lot specific data (including water content).
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Chlorothricin is a spirotetronic acid macrolide antibiotic produced by Streptomyces antibioticus. Chlorothricin demonstrates inhibition of cholesterol biosynthesis by impeding on the mevalonate pathway. Chlorothricin is described to inhibit pyruvate carboxylases isolated from both Bacillus stearothermophilus and chicken livers, and to inhibit acetyl coenzyme A (CoASAc)-independent oxalacetate synthesis by pyruvate carboxylase of rat liver.


References

1. Schindler, P.W. and Zähner, H. 1973. Eur. J. Biochem. 39: 591-600. PMID: 4775066
2. Schindler, P.W. and Scrutton, M.C. 1975. Eur. J. Biochem. 55: 543-553. PMID: 1175611
3. Mascaretti, O.A., et al. 1981. Biochemistry. 20: 919-924. PMID: 7011379
4. Kawashima, A., et al. 1992. J. Antibiot. 45: 207-212. PMID: 1556012
5. Jia, X.Y., et al. 2006. Chem. Biol. 13: 575-585. PMID: 16793515
6. Nakajima, H., et al. 2007. Biochem. Biophys. Res. Commun. 356: 260-265. PMID: 17350598
7. Sun, Y., et al. 2008. Chembiochem. 9: 150-156. PMID: 18046685

Appearance :
Powder
Physical State :
Solid
Derived From :
Streptomyces sp. MST-AS5342
Solubility :
Solubility: ethyl acetate, ethanol, methanol, DMF or DMSO.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6438432
SMILES :
C[C@@H]1C[C@@]23[C@H](/C=C/CCCC[C@@H]4C=C[C@H]5[C@H]([C@@]4(C(=O)OC(=C(O2)O)C3=O)C)CCC[C@@H]5OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)O)OC(=O)C8=C(C=CC(=C8C)Cl)OC)O)C=C1C(=O)O

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Certificate of Analysis

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Rated 5 out of 5 by from Terekhova Terekhova, LP. et al. (PubMed 19227116) investigated the taxonomic properties of Chlorothricin. The antibiotic showed activity against grampositive bacteria and fungi. -SCBT Publication Review
Date published: 2015-07-01
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