Chloroform is a common laboratory reagent favored for use as a solvent due to the compounds relative unreactivity and miscibility with most organic compounds. Chloroform is also used in organic synthesis as a source for CCl2. In the swine tracheal smooth muscle, chloroform has been demonstrated to directly and in a concentration dependent manner induce contractions. It has been observed that Chloroform can release Ca2+ from ryanodine sensitive receptors in chloroform-induced contraction in swine tracheal smooth muscle. At concentrations of 100 and 250 ppm in mouse splenocyte, basal proliferation was increased yet a decrease in circulating neutrophils was documented.
1. Lin, Y.R., et al. 2002. Toxicol. Appl. Pharmacol. 183: 146-151. PMID: 12387754
2. Auttachoat, W., et al. 2009. Drug Chem Toxicol. 32: 77-87. PMID: 19514942
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