Chloramphenicol A protein translation blocking antibiotic

Chloramphenicol (CAS 56-75-7)

Chloramphenicol | CAS 56-75-7 is rated 5.0 out of 5 by 1.
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Synonym: Chlornitromycin; Chloromycetin; Chlorocid; Levomycetin; Halomycetin; Levomicetina
Application: A protein translation blocking antibiotic
CAS Number: 56-75-7
Purity: ≥98%
Molecular Weight: 323.13
Molecular Formula: C11H12Cl2N2O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Chloramphenicol is a broad spectrum antibiotic which inhibits translation on the 50S ribosomal subunit at the peptidyltransferase step. It is usually bacteristatic and effective against a wide range of gram-positive and gram-negative organisms. Chloramphenicol exhibits anti-rickettsial activity and is also active against chlamydias of the psittacosis-lymphogranuloma group. Obtained from cultures of the soil bacterium Streptomyces venuzuelae isolated from the moon snail, Lunatia heros and produced synthetically. Useful for the selection of the bacterial CAT gene.


References

1. Gottlieb, D. and Bhattacharyya, P.K. 1948. J. Bacteriol. 55: 409-417. PMID: 18902264
2. Bartz, Q.R. 1948. J. Biol. Chem. 172: 445-450. PMID: 18901162
3. Shalit, I. and Marks, M.I. 1984. Drugs. 28: 281-291. PMID: 6386425
4. Falagas, M.E., et al. 2008. Expert Rev Anti Infect Ther. 6: 593-600. PMID: 18847400
5. Hartmann, C., et al. 2010. J Med Microbiol. PMID: 20634329

Usage :
• Effective working concentration of 5 µg/ml.
Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in water (2.5 g/l) at 25° C, methanol, ethanol, butanol, ethyl acetate, acetone, DMSO, and propylene glycol (150.8 mg/ml).
Storage :
Store at room temperature
Melting Point :
149-152° C
Boiling Point :
~644.9° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
Optical Activity :
α20/D +19°, c = 6 in ethanol
IC50 :
Staphylococcus lentus: IC50 = 2.3 µM; Xanthomonas campestris: IC50 = 3.6 µM; Staphylococcus aureus: IC50 = >250 µg/ml
Ki Data :
Escherichia coli: Ki= 700 nM
pK Values :
pKa: 5.5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AB6825000
PubChem CID :
5959
Merck Index :
14: 2077
MDL Number :
MFCD00078159
EC Number :
200-287-4
Beilstein Registry :
2225532
SMILES :
OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)C1=CC=C(C=C1)[N+]([O-])=O

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Chloramphenicol  Product Citations

See how others have used Chloramphenicol. Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 20616070  Köpke, M. et al. 2010. Proc. Natl. Acad. Sci. U.S.A. 107: 13087-13092.

PMID: # 20624955  Pruitt, RN. et al. 2010. Proc. Natl. Acad. Sci. U.S.A. 107: 13467-13472.

PMID: # 16988235  Balsara, Z. et al. 2006. Infection and Immunity. 74: 5602-5608.

PMID: # 15284440  Luker, KE. et al. 2004. Proc. Natl. Acad. Sci. U.S.A. 101: 12288-12293.

PMID: # 6943583  Blanc, H. et al. 1981. Proc. Natl. Acad. Sci. U.S.A. 78: 3789-3793.

PMID: # 329286  Shay, JW. et al. 1977. Proc. Natl. Acad. Sci. U.S.A. 74: 2461-2464.

PMID: # 4525288  Bunn, CL. et al. 1974. Proc. Natl. Acad. Sci. U.S.A. 71: 1681-1685.

PMID: # 5256419  Levine, AJ. et al. 1969. Proc. Natl. Acad. Sci. U.S.A. 62: 1226-1228.

PMID: # 16590991  Sarkissian, I. et al. 1962. Proc. Natl. Acad. Sci. U.S.A. 48: 1513-1519.

Citations 1 to 9 of 9 total
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Rated 5 out of 5 by from K pke K pke, et. al. (PubMed ID 20616070) used chloramphenicol to screen for successfully transformed bacteria. -SCBT Publication Review
Date published: 2015-05-15
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