Chetomin An antibacterial agent and inhibitor of HIF

Chetomin (CAS 1403-36-7)

Chetomin | CAS 1403-36-7 is rated 5.0 out of 5 by 1.
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Synonym: Chaetomin; NSC 289491
Application: An antibacterial agent and inhibitor of HIF
CAS Number: 1403-36-7
Purity: >98%
Molecular Weight: 710.86
Molecular Formula: C31H30N6O6S4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Chetomin is reported to be an antibiotic metabolite of Chaetomium spp. which contains bacteriostatic effects on Gram-positive bacteria. Mechanistic studies suggest that Chetomin inhibits the division and separation of cells in cultures of B. fibrisolvens D1. Chetomin inhibits HIF (hypoxia-inducing factor) binding to the transcriptional coactivator p300. Chetomin disruption of HIF is believed to be done via a change in the structure of the CH1 domain of p300 which prevents interaction with HIF-1α and HIF-2α. Inhibition of this interaction has been reported to attenuate hypoxia-inducible transcription.


References

1. Jen, W.C. and Jones, G.A. 1983. Can. J. Microbiol. 29: 1399-1404. PMID: 6686488
2. Kung, A.L., et al. 2004. Cancer Cell. 6: 33-43. PMID: 15261140
3. Fujimoto, H., et al. 2004. J. Nat. Prod. 67: 98-102. PMID: 14738397
4. Staab, A., et al. 2007. BMC Cancer. 7: 213. PMID: 17999771

Usage :
Toxic.
Physical State :
Solid
Derived From :
Chaetomium sp.
Solubility :
Soluble in DMSO(5 mg/ml), ethyl acetate or pyridine; fairly soluble in methanol, 100% ethanol; Insoluble in water.
Storage :
Store at -20° C
Density :
1.79 g/cm3 (Predicted)
Refractive Index :
n20D 1.89 (Predicted)
IC50 :
Secreted VEGF: IC50 = 20 nM (Hep38 cells); Cellular VEGF: IC50 <10 nM (Hep38 cells)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
FM3038000
PubChem CID :
73583
SMILES :
CN1C(=O)C2(N(C(=O)C1(SS2)CC3=CN(C4=CC=CC=C43)C56CC78C(=O)N(C(C(=O)N7C5NC9=CC=CC=C69)(SS8)CO)C)C)CO

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Certificate of Analysis

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Chetomin  Product Citations

See how others have used Chetomin. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 27271565  Fecher, RA. et al. 2016. J. Immunol. 197: 565-79.

PMID: # 24686084  Park, SH. et al. 2014. Cellular signalling. 26: 1506-13.

PMID: # 24398013  Park, JK. et al. 2014. Placenta. 35: 109-16.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Staab et al Staab et al. (PubMed ID 17999771) found that chetomin inhibited HIF-1 expression following hypoxia and also radiosensitized hypoxic HT in 1080 human fibrosarcoma cells. -SCBT Publication Review
Date published: 2015-04-06
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